DegronMD

Uniprot ID: Q03828

Source protein: Homeobox even-skipped homolog protein 2

Source gene: EVX2

Class: DEG_SPOP_SBC_1

Location: 151:155

E3 ligase: SPOP

DEGRON score: 0.9471

ASA_SCORE: 75.02

COIL: 0.8788

CONS_SCORE: 0.3973

DSS_SCORE: 0.4841

HELIX: 0.0328

FCONS_SCORE: 1.0191

RIG_SCORE: 0.6503

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A145E	TCGA-86-8073	LUAD	TCGA	AGTTT	DEG_SPOP_SBC_1	0.1667
p.A145E	DO23624	LUAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1667
p.S160P	TCGA-94-8490	LUSC	TCGA	AGTTT	DEG_SPOP_SBC_1	0.1944
p.S160P	DO52021	LUSC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.S149L	TCGA-BR-A4QL	STAD	TCGA	AGTTT	DEG_SPOP_SBC_1	0.2778
p.S149L	DO38723	STAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2778
p.T154M	TCGA-CV-7236	HNSC	TCGA	AGTTT	DEG_SPOP_SBC_1	0.7423
p.T154M	DO15230	HNSC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.7423
p.G143V	DO52626	BOCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1111
p.A151V	DO228917	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.5825
p.L165M	DO228978	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0556
p.S164I	DO231096	LUSC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0833
p.G141A	SIDM00845	Burkitt's Lymphoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.0556
p.S160L	SIDM00496	Thyroid Gland Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.S160L	ACH-001350	Thyroid Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.1944
p.S160L	HTC-C3	thyroid	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.A150P	ACH-000431	Lung Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	449:453	AGTTT	SPOP	0.9893	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1597:1601	AGTTT	SPOP	0.9677	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	221:225	AGTTT	SPOP	0.9799	More...
Q08708	CMRF35-like molecule 6	DEG_SPOP_SBC_1	134:138	AGTTT	SPOP	0.9394	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	437:441	AGTTT	SPOP	0.9896	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3464:3468	AGTTT	SPOP	0.9981	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	37:41	AGTTT	SPOP	0.9961	More...
Q9Y2H1	Serine/threonine-protein kinase 38-like	DEG_SPOP_SBC_1	5:9	AGTTT	SPOP	0.9978	More...
Q9Y6W6	Dual specificity protein phosphatase 10	DEG_SPOP_SBC_1	99:103	AGTTT	SPOP	0.9358	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_SPOP_SBC_1	151:155	AGTTT	SPOP	0.9471	More...
O43247	Testis-expressed protein 33	DEG_SPOP_SBC_1	7:11	AGTTT	SPOP	0.7629	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1337:1341	AGTTT	SPOP	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons