DegronMD

Uniprot ID: Q9Y2H1

Source protein: Serine/threonine-protein kinase 38-like

Source gene: STK38L

Class: DEG_SPOP_SBC_1

Location: 5:9

E3 ligase: SPOP

DEGRON score: 0.9978

ASA_SCORE: 78.12

COIL: 0.958

CONS_SCORE: 0.2391

DSS_SCORE: 0.6835

HELIX: 0.0274

FCONS_SCORE: 0.725

RIG_SCORE: 0.7171

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A5T	TCGA-06-5416	GBM	TCGA	AGTTT	DEG_SPOP_SBC_1	0.7139
p.A5T	DO10880	GBM	ICGC	AGTTT	DEG_SPOP_SBC_1	0.7139
p.P12H	TCGA-BF-A1PU	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	0.25
p.P12H	DO50278	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	0.25
p.N15S	TCGA-CG-4460	STAD	TCGA	AGTTT	DEG_SPOP_SBC_1	0.1667
p.N15S	DO38427	STAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1667
p.E19K	TCGA-D3-A3C8	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	0.0556
p.E19K	DO47636	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0556
p.R18W	TCGA-XK-AAIW	PRAD	TCGA	AGTTT	DEG_SPOP_SBC_1	0.0833
p.R18W	DO27025	LUSC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0833
p.R18W	DO51407	PRAD	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0833
p.R12W	DO48566	BLCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.25
p.R12W	DO26858	LUSC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.25
p.R12W	DO41871	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.25
p.E4Q	DO590	BLCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.3056
p.T4M	DO233823	GACA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.3056
p.T4M	ACH-001664	Gastric Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.3056
p.P12S	DO220886	MELA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.25
p.V11L	DO32113	OV	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2778
p.T9A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	AGTTT	DEG_SPOP_SBC_1	0.7139
p.T9A	ACH-000920	Leukemia	CCLE	AGTTT	DEG_SPOP_SBC_1	0.7139
p.T9A	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	449:453	AGTTT	SPOP	0.9893	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1597:1601	AGTTT	SPOP	0.9677	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	221:225	AGTTT	SPOP	0.9799	More...
Q08708	CMRF35-like molecule 6	DEG_SPOP_SBC_1	134:138	AGTTT	SPOP	0.9394	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	437:441	AGTTT	SPOP	0.9896	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3464:3468	AGTTT	SPOP	0.9981	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	37:41	AGTTT	SPOP	0.9961	More...
Q9Y2H1	Serine/threonine-protein kinase 38-like	DEG_SPOP_SBC_1	5:9	AGTTT	SPOP	0.9978	More...
Q9Y6W6	Dual specificity protein phosphatase 10	DEG_SPOP_SBC_1	99:103	AGTTT	SPOP	0.9358	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_SPOP_SBC_1	151:155	AGTTT	SPOP	0.9471	More...
O43247	Testis-expressed protein 33	DEG_SPOP_SBC_1	7:11	AGTTT	SPOP	0.7629	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1337:1341	AGTTT	SPOP	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons