DegronMD

Uniprot ID: P52948

Source protein: Nuclear pore complex protein Nup98-Nup96

Source gene: NUP98

Class: DEG_SPOP_SBC_1

Location: 221:225

E3 ligase: SPOP

DEGRON score: 0.9799

ASA_SCORE: 55.12

COIL: 0.7666

CONS_SCORE: 0.4104

DSS_SCORE: 0.5833

HELIX: 0.0436

FCONS_SCORE: 0.9685

RIG_SCORE: 0.6742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N217K	DO229022	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2222
p.T225N	DO229045	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.7055
p.G214A	DO229211	THCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1389
p.G214S	ACH-000982	Colon/Colorectal Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	449:453	AGTTT	SPOP	0.9893	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1597:1601	AGTTT	SPOP	0.9677	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	221:225	AGTTT	SPOP	0.9799	More...
Q08708	CMRF35-like molecule 6	DEG_SPOP_SBC_1	134:138	AGTTT	SPOP	0.9394	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	437:441	AGTTT	SPOP	0.9896	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3464:3468	AGTTT	SPOP	0.9981	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	37:41	AGTTT	SPOP	0.9961	More...
Q9Y2H1	Serine/threonine-protein kinase 38-like	DEG_SPOP_SBC_1	5:9	AGTTT	SPOP	0.9978	More...
Q9Y6W6	Dual specificity protein phosphatase 10	DEG_SPOP_SBC_1	99:103	AGTTT	SPOP	0.9358	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_SPOP_SBC_1	151:155	AGTTT	SPOP	0.9471	More...
O43247	Testis-expressed protein 33	DEG_SPOP_SBC_1	7:11	AGTTT	SPOP	0.7629	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1337:1341	AGTTT	SPOP	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons