DegronMD - Q08708(CD300C)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A139V	TCGA-AA-3977	COAD	TCGA	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.A139V	DO8730	COAD	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.P142S	TCGA-BF-AAP2	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.2222
p.P142S	DO219466	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.2222
p.P133Q	TCGA-BJ-A2N8	THCA	TCGA	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.P133Q	DO48068	THCA	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.P133L	TCGA-BR-8078	STAD	TCGA	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.P133L	DO222815	BTCA	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.P133L	DO38288	STAD	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.E128Q	TCGA-C5-A7X3	CESC	TCGA	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1667
p.E128Q	DO49893	CESC	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1667
p.P142L	TCGA-DA-A3F8	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.2222
p.P142L	DO37418	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.2222
p.S140F	TCGA-EB-A5UN	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.2778
p.S140F	DO47267	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.2778
p.A134V	TCGA-EI-6882	READ	TCGA	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.5825
p.A134V	DO36531	READ	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.5825
p.A139T	TCGA-FI-A2D5	UCEC	TCGA	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.A139T	DO41331	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.S141R	TCGA-WB-A817	PCPG	TCGA	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.25
p.S141R	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.25
p.S141R	ACH-000858	Lung Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.25
p.S141R	KNS-62	lung	COSMIC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.25
p.A139D	DO229019	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.I124V	DO229253	THCA	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.0556
p.S141G	DO229227	THCA	ICGC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.25
p.V127A	SIDM00571	Pancreatic Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1389
p.V127A	ACH-000108	Pancreatic Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1389
p.V127A	KP-3	pancreas	COSMIC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1389
p.Q143H	SIDM00118	Colorectal Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1944
p.Q143H	ACH-001081	Colon/Colorectal Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1944
p.Q143H	HCC2998	large intestine	COSMIC	AGTTT	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD300C

UniProt ID: Q08708

Entrez ID: 10871

Protein name: CMRF35-like molecule 6 (CLM-6) (CD300 antigen-like family member C) (CMRF35-A1) (CMRF-35) (Immunoglobulin superfamily member 16) (IgSF16) (CD antigen CD300c)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CD300C in