DegronMD

Uniprot ID: Q5HYC2

Source protein: Uncharacterized protein KIAA2026

Source gene: KIAA2026

Class: DEG_SPOP_SBC_1

Location: 1337:1341

E3 ligase: SPOP

DEGRON score: 0.9403

ASA_SCORE: 82.72

COIL: 0.91

CONS_SCORE: 0.2534

DSS_SCORE: 0.3619

HELIX: 0.0114

FCONS_SCORE: 0.8959

RIG_SCORE: 0.671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1342A	TCGA-UY-A8OB	BLCA	TCGA	AGTTT	DEG_SPOP_SBC_1	0.3056
p.H1345Y	DO52202	LIHC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2222
p.D1351N	DO42033	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0556
p.T1347I	DO41584	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1667
p.G1338E	SIDM00506	Small Cell Lung Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.6087
p.G1338E	ACH-000508	Lung Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.6087
p.G1338E	COR-L88	lung	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.6087
p.A1332V	SIDM00660	Colorectal Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.A1332V	ACH-000985	Colon/Colorectal Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.1944
p.A1332V	LS-411N	large_intestine	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.1944
p.T1339K	ACH-000871	Lung Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	0.7306
p.K1340R	LNCaP-Clone-FGC	prostate	COSMIC	AGTTT	DEG_SPOP_SBC_1	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	449:453	AGTTT	SPOP	0.9893	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1597:1601	AGTTT	SPOP	0.9677	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	221:225	AGTTT	SPOP	0.9799	More...
Q08708	CMRF35-like molecule 6	DEG_SPOP_SBC_1	134:138	AGTTT	SPOP	0.9394	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	437:441	AGTTT	SPOP	0.9896	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3464:3468	AGTTT	SPOP	0.9981	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	37:41	AGTTT	SPOP	0.9961	More...
Q9Y2H1	Serine/threonine-protein kinase 38-like	DEG_SPOP_SBC_1	5:9	AGTTT	SPOP	0.9978	More...
Q9Y6W6	Dual specificity protein phosphatase 10	DEG_SPOP_SBC_1	99:103	AGTTT	SPOP	0.9358	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_SPOP_SBC_1	151:155	AGTTT	SPOP	0.9471	More...
O43247	Testis-expressed protein 33	DEG_SPOP_SBC_1	7:11	AGTTT	SPOP	0.7629	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1337:1341	AGTTT	SPOP	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons