DegronMD

Uniprot ID: Q7Z5P9

Source protein: Mucin-19

Source gene: MUC19

Class: DEG_SPOP_SBC_1

Location: 3464:3468

E3 ligase: SPOP

DEGRON score: 0.9981

ASA_SCORE: 78.96

COIL: 0.8278

CONS_SCORE: 0.3085

DSS_SCORE: 0.4999

HELIX: 0.019

FCONS_SCORE: 1

RIG_SCORE: 0.7285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3477K	DO225032	BRCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0833
p.S3461L	DO6144	BRCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.25
p.G3476E	DO222585	COCA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1111
p.V3474L	DO218136	GACA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.1667
p.A3464V	DO230659	LAML	ICGC	AGTTT	DEG_SPOP_SBC_1	0.5825
p.P3472A	DO230659	LAML	ICGC	AGTTT	DEG_SPOP_SBC_1	0.2222
p.V3454M	DO220892	MELA	ICGC	AGTTT	DEG_SPOP_SBC_1	0.0556
p.G3466W	DO42825	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	0.7825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49840	Glycogen synthase kinase-3 alpha	DEG_SPOP_SBC_1	449:453	AGTTT	SPOP	0.9893	More...
P51610	Host cell factor 1	DEG_SPOP_SBC_1	1597:1601	AGTTT	SPOP	0.9677	More...
P52948	Nuclear pore complex protein Nup98-Nup96	DEG_SPOP_SBC_1	221:225	AGTTT	SPOP	0.9799	More...
Q08708	CMRF35-like molecule 6	DEG_SPOP_SBC_1	134:138	AGTTT	SPOP	0.9394	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	437:441	AGTTT	SPOP	0.9896	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	3464:3468	AGTTT	SPOP	0.9981	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	37:41	AGTTT	SPOP	0.9961	More...
Q9Y2H1	Serine/threonine-protein kinase 38-like	DEG_SPOP_SBC_1	5:9	AGTTT	SPOP	0.9978	More...
Q9Y6W6	Dual specificity protein phosphatase 10	DEG_SPOP_SBC_1	99:103	AGTTT	SPOP	0.9358	More...
Q03828	Homeobox even-skipped homolog protein 2	DEG_SPOP_SBC_1	151:155	AGTTT	SPOP	0.9471	More...
O43247	Testis-expressed protein 33	DEG_SPOP_SBC_1	7:11	AGTTT	SPOP	0.7629	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1337:1341	AGTTT	SPOP	0.9403	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons