DegronMD - Q9UJD0(RIMS3)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A13S	TCGA-17-Z045	LUAD	TCGA	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1944
p.A42T	TCGA-32-1977	GBM	TCGA	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.A42T	TCGA-AA-A010	COAD	TCGA	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.A42T	TCGA-CN-4730	HNSC	TCGA	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.A42T	DO12076	GBM	ICGC	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.A42T	DO14234	HNSC	ICGC	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.R45W	TCGA-A2-A4S1	BRCA	TCGA	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2222
p.R45W	DO44216	BRCA	ICGC	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2222
p.G12E	TCGA-A5-A0G1	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.G12E	DO42472	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.R19W	TCGA-AA-3821	COAD	TCGA	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7523
p.R19W	TCGA-AD-A5EJ	COAD	TCGA	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7523
p.R19W	DO9314	COAD	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7523
p.R19W	DO50090	COAD	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7523
p.R19W	DO233652	GACA	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7523
p.R19L	TCGA-D3-A1Q3	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7316
p.R19L	DO47509	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7316
p.G25C	TCGA-D3-A2JK	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.G25C	DO37619	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.G38W	TCGA-D3-A3CB	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.6714
p.G38W	DO47386	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.6714
p.Q31K	TCGA-D3-A3CE	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0833
p.Q31K	TCGA-D3-A3CE	SKCM	TCGA	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1667
p.Q31K	DO37405	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0833
p.Q31K	DO37405	SKCM	ICGC	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1667
p.E26K	TCGA-EB-A3Y7	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2222
p.E26K	DO37499	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2222
p.E26K	SIDM01175	Other Sarcomas	GDSC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2222
p.E26K	ACH-002309	Sarcoma	CCLE	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2222
p.E26K	SW684	soft tissue	COSMIC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2222
p.R19Q	TCGA-ER-A193	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.6218
p.R19Q	DO47368	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.6218
p.S22R	TCGA-VS-A8EJ	CESC	TCGA	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.8538
p.S22R	DO51622	CESC	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.8538
p.S11F	TCGA-W3-A828	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1389
p.S11F	DO51273	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1389
p.G29R	DO233270	GACA	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1389
p.G29R	DO233270	GACA	ICGC	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.1111
p.A33D	DO229018	LICA	ICGC	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2222
p.P8S	DO220885	MELA	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0556
p.S22T	DO220891	MELA	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7116
p.S10A	DO38404	STAD	ICGC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1111
p.G12R	SIDM00985	Burkitt's Lymphoma	GDSC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.G12R	SIDM00128	Head and Neck Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.G12R	SIDM01183	Other Solid Cancers	GDSC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.G12R	SIDM00686	Endometrial Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.G12R	SIDM00140	Melanoma	GDSC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.G34W	SIDM00664	Pancreatic Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.25
p.G34W	ACH-000178	Pancreatic Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.25
p.G25S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.G25S	ACH-002256	Leukemia	CCLE	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.G25S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.25
p.A37V	SIDM00142	Endometrial Carcinoma	GDSC	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.5825
p.A37V	ACH-000864	Endometrial/Uterine Cancer	CCLE	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.5825
p.A37V	COLO-684	endometrium	COSMIC	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.5825
p.G34R	ACH-000918	Leukemia	CCLE	AGTTT	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.25
p.V17A	ACH-001664	Gastric Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIMS3

UniProt ID: Q9UJD0

Entrez ID: 9783

Protein name: Regulating synaptic membrane exocytosis protein 3 (Nim3) (RIM3 gamma) (Rab-3-interacting molecule 3) (RIM 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIMS3 in