DegronMD

Uniprot ID: Q9UJD0

Source protein: Regulating synaptic membrane exocytosis protein 3

Source gene: RIMS3

Class: DEG_SPOP_SBC_1

Location: 18:22

E3 ligase: SPOP

DEGRON score: 0.9843

ASA_SCORE: 81.16

COIL: 0.701

CONS_SCORE: 0.5799

DSS_SCORE: 0.4987

HELIX: 0.0252

FCONS_SCORE: 1.4493

RIG_SCORE: 0.6877

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A13S	TCGA-17-Z045	LUAD	TCGA	VRSSS	DEG_SPOP_SBC_1	0.1944
p.G12E	TCGA-A5-A0G1	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.1667
p.G12E	DO42472	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1667
p.R19W	TCGA-AA-3821	COAD	TCGA	VRSSS	DEG_SPOP_SBC_1	0.7523
p.R19W	TCGA-AD-A5EJ	COAD	TCGA	VRSSS	DEG_SPOP_SBC_1	0.7523
p.R19W	DO9314	COAD	ICGC	VRSSS	DEG_SPOP_SBC_1	0.7523
p.R19W	DO50090	COAD	ICGC	VRSSS	DEG_SPOP_SBC_1	0.7523
p.R19W	DO233652	GACA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.7523
p.R19L	TCGA-D3-A1Q3	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.7316
p.R19L	DO47509	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.7316
p.G25C	TCGA-D3-A2JK	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.25
p.G25C	DO37619	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.25
p.Q31K	TCGA-D3-A3CE	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.0833
p.Q31K	DO37405	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0833
p.E26K	TCGA-EB-A3Y7	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.2222
p.E26K	DO37499	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.2222
p.E26K	SIDM01175	Other Sarcomas	GDSC	VRSSS	DEG_SPOP_SBC_1	0.2222
p.E26K	ACH-002309	Sarcoma	CCLE	VRSSS	DEG_SPOP_SBC_1	0.2222
p.E26K	SW684	soft_tissue	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.2222
p.R19Q	TCGA-ER-A193	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.6218
p.R19Q	DO47368	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.6218
p.S22R	TCGA-VS-A8EJ	CESC	TCGA	VRSSS	DEG_SPOP_SBC_1	0.8538
p.S22R	DO51622	CESC	ICGC	VRSSS	DEG_SPOP_SBC_1	0.8538
p.S11F	TCGA-W3-A828	SKCM	TCGA	VRSSS	DEG_SPOP_SBC_1	0.1389
p.S11F	DO51273	SKCM	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1389
p.G29R	DO233270	GACA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1389
p.P8S	DO220885	MELA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.0556
p.S22T	DO220891	MELA	ICGC	VRSSS	DEG_SPOP_SBC_1	0.7116
p.S10A	DO38404	STAD	ICGC	VRSSS	DEG_SPOP_SBC_1	0.1111
p.G12R	SIDM00985	Burkitt's Lymphoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.1667
p.G12R	SIDM00128	Head and Neck Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.1667
p.G12R	SIDM01183	Other Solid Cancers	GDSC	VRSSS	DEG_SPOP_SBC_1	0.1667
p.G12R	SIDM00686	Endometrial Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.1667
p.G12R	SIDM00140	Melanoma	GDSC	VRSSS	DEG_SPOP_SBC_1	0.1667
p.G25S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VRSSS	DEG_SPOP_SBC_1	0.25
p.G25S	ACH-002256	Leukemia	CCLE	VRSSS	DEG_SPOP_SBC_1	0.25
p.G25S	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VRSSS	DEG_SPOP_SBC_1	0.25
p.V17A	ACH-001664	Gastric Cancer	CCLE	VRSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_SPOP_SBC_1	706:710	VRSSS	SPOP	0.9811	More...
P01375	Tumor necrosis factor	DEG_SPOP_SBC_1	77:81	VRSSS	SPOP	0.5812	More...
P38159	RNA-binding motif protein, X chromosome	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9851	More...
Q6ZSJ9	Protein shisa-6	DEG_SPOP_SBC_1	248:252	VRSSS	SPOP	0.8915	More...
Q70CQ4	Ubiquitin carboxyl-terminal hydrolase 31	DEG_SPOP_SBC_1	1196:1200	VRSSS	SPOP	0.697	More...
Q86VV4	Ran-binding protein 3-like	DEG_SPOP_SBC_1	73:77	VRSSS	SPOP	0.9807	More...
Q9UJD0	Regulating synaptic membrane exocytosis protein 3	DEG_SPOP_SBC_1	18:22	VRSSS	SPOP	0.9843	More...
A8K979	ERI1 exoribonuclease 2	DEG_SPOP_SBC_1	565:569	VRSSS	SPOP	0.9149	More...
Q5VVW2	GTPase-activating Rap/Ran-GAP domain-like protein 3	DEG_SPOP_SBC_1	950:954	VRSSS	SPOP	0.6326	More...
Q96E39	RNA binding motif protein, X-linked-like-1	DEG_SPOP_SBC_1	171:175	VRSSS	SPOP	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRSSS

Degron related mutations and impact score

Drug responses associated with RIMS3 mutations

All proteins holding degron of VRSSS