DegronMD - O95819(MAP4K4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R703C	TCGA-32-2638	GBM	TCGA	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.25
p.R703C	TCGA-PK-A5HB	ACC	TCGA	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.25
p.G701R	TCGA-A6-5661	COAD	TCGA	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.1944
p.A619T	TCGA-AJ-A3EK	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1667
p.A619T	DO41584	UCEC	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1667
p.R719H	TCGA-AP-A051	UCEC	TCGA	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.0833
p.L835I	TCGA-AP-A1DV	UCEC	TCGA	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.25
p.P829Q	TCGA-D3-A1Q6	SKCM	TCGA	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.7035
p.T809M	TCGA-D5-6541	COAD	TCGA	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation blocking phosphorylation signal	0.75
p.T809M	TCGA-D5-6541	COAD	TCGA	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation blocking phosphorylation signal	0.6111
p.T809M	TCGA-PG-A6IB	UCEC	TCGA	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation blocking phosphorylation signal	0.75
p.T809M	TCGA-PG-A6IB	UCEC	TCGA	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation blocking phosphorylation signal	0.6111
p.S717C	TCGA-ED-A459	LIHC	TCGA	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation blocking phosphorylation signal	0.5833
p.T828A	TCGA-EE-A182	SKCM	TCGA	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.825
p.L804F	TCGA-GM-A2DI	BRCA	TCGA	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation altering degron motif	0.587
p.S842F	TCGA-GN-A4U4	SKCM	TCGA	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation blocking phosphorylation signal	0.5
p.V623L	DO44097	BLCA	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2778
p.E812K	DO518	BLCA	ICGC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation rewiring degron network	0.2222
p.E812K	DO518	BLCA	ICGC	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.25
p.W853C	DO8634	COAD	ICGC	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation blocking phosphorylation signal	0.6944
p.S847Y	DO230313	COCA	ICGC	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation rewiring degron network	0.0833
p.P719S	DO228075	EOPC	ICGC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.0833
p.E635K	DO234203	ESAD	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1667
p.S636F	DO234373	ESAD	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1389
p.L835F	DO228648	GACA	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.25
p.E627G	DO233276	GACA	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7199
p.I837N	DO18938	KIRC	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.1944
p.D717Y	DO228986	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation blocking phosphorylation signal	0.5833
p.D717Y	DO229041	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation blocking phosphorylation signal	0.5833
p.W799C	DO229022	LICA	ICGC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation rewiring degron network	0.2222
p.A629S	DO229031	LICA	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7588
p.A629S	DO229035	LICA	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7588
p.R700W	DO229055	LICA	ICGC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation blocking phosphorylation signal	0.6111
p.R700W	DO41927	UCEC	ICGC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation blocking phosphorylation signal	0.6111
p.M618I	DO23444	LINC	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1389
p.S703L	DO23846	LUAD	ICGC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.25
p.A852P	DO223665	LUAD	ICGC	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation blocking phosphorylation signal	0.6667
p.Y834C	DO26250	LUAD	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation blocking phosphorylation signal	0.7222
p.E720D	DO26814	LUSC	ICGC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.0556
p.D822N	DO27652	LUSC	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.25
p.D822N	DO27652	LUSC	ICGC	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.2778
p.R815C	DO227933	PBCA	ICGC	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.8301
p.R815C	DO223286	UCEC	ICGC	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.8301
p.G821V	DO47100	RECA	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.2222
p.G821V	DO47100	RECA	ICGC	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.3056
p.T631A	DO37814	SKCM	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation blocking phosphorylation signal	0.7222
p.P632Q	DO37450	SKCM	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.25
p.E835K	DO48665	SKCM	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.25
p.R793C	DO38823	STAD	ICGC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation rewiring degron network	0.0556
p.N708K	DO38404	STAD	ICGC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation altering degron motif	0.6918
p.N634S	DO38344	STAD	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1944
p.V620A	DO229259	THCA	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1944
p.A629T	DO229253	THCA	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7139
p.R713G	DO229272	THCA	ICGC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.25
p.S821N	DO42280	UCEC	ICGC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.2222
p.S821N	DO42280	UCEC	ICGC	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.3056
p.L638I	DO43186	UCEC	ICGC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.0833
p.T819S	DO52419	UCEC	ICGC	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.7116
p.I804R	DO41758	UCEC	ICGC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation altering degron motif	0.8102
p.F861C	DO41903	UCEC	ICGC	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation altering degron motif	0.7108
p.F861C	DO41799	UCEC	ICGC	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation altering degron motif	0.7108
p.V807I	SIDM00985	Burkitt's Lymphoma	GDSC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation altering degron motif	0.7076
p.V807I	BL-41	haematopoietic and lymphoid tissue	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation altering degron motif	0.7076
p.Q619E	SIDM00789	Colorectal Carcinoma	GDSC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1667
p.Q619E	HCT-15	large intestine	COSMIC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1667
p.K701N	SIDM00193	Colorectal Carcinoma	GDSC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.1944
p.K701N	SNU-81	large intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.1944
p.G827S	SIDM00084	Glioblastoma	GDSC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.6993
p.G827S	SF295	central nervous system	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.6993
p.E802V	SIDM00783	Colorectal Carcinoma	GDSC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation rewiring degron network	0.3056
p.E802V	HCT-116	large intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation rewiring degron network	0.3056
p.R626T	ACH-000710	Lung Cancer	CCLE	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.6765
p.M801L	ACH-000786	Lymphoma	CCLE	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation blocking phosphorylation signal	0.7222
p.E628G	ACH-000946	Endometrial/Uterine Cancer	CCLE	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7199
p.R812W	ACH-000950	Colon/Colorectal Cancer	CCLE	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation rewiring degron network	0.2222
p.R812W	ACH-000950	Colon/Colorectal Cancer	CCLE	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.25
p.R812W	LoVo	large intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation rewiring degron network	0.2222
p.R812W	LoVo	large intestine	COSMIC	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation rewiring degron network	0.25
p.Q870H	ACH-000994	Endometrial/Uterine Cancer	CCLE	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation blocking phosphorylation signal	0.5278
p.T621K	Ca9-22	upper aerodigestive tract	COSMIC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.2222
p.S635T	C3A	liver	COSMIC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1667
p.E832V	HCT-116	large intestine	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.7693
p.S860P	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation altering degron motif	0.6752
p.S627T	C3A	liver	COSMIC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7116
p.S841I	NCI-H1693	lung	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.0833
p.G826S	SF295	central nervous system	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.6993
p.K700N	SNU-81	large intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation blocking phosphorylation signal	0.6111
p.A848V	LIM1215	large intestine	COSMIC	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation rewiring degron network	0.1111
p.V636I	BL-41	haematopoietic and lymphoid tissue	COSMIC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1389
p.R714Q	SNU-81	large intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.2222
p.V837I	BL-41	haematopoietic and lymphoid tissue	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.1944
p.R815W	LoVo	large intestine	COSMIC	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.8634
p.A797V	LIM1215	large intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation rewiring degron network	0.1667
p.R696W	LoVo	large intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation blocking phosphorylation signal	0.5
p.R702W	LoVo	large intestine	COSMIC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation rewiring degron network	0.2222
p.V797E	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation rewiring degron network	0.1667
p.V833I	BL-41	haematopoietic and lymphoid tissue	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation rewiring degron network	0.3056
p.E637V	HCT-116	large intestine	COSMIC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation rewiring degron network	0.1111
p.E828V	HCT-116	large intestine	COSMIC	PAMTPSKE	DEG_SCF_FBW7_2	825:832	Mutation altering degron motif	0.7693
p.V627E	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation altering degron motif	0.7693
p.V794E	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation rewiring degron network	0.0833
p.R795C	NCI-H630	large intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation rewiring degron network	0.1111
p.S861P	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation altering degron motif	0.6752
p.T869K	Ca9-22	upper aerodigestive tract	COSMIC	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation rewiring degron network	0.1111
p.V816L	Daudi	haematopoietic and lymphoid tissue	COSMIC	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation altering degron motif	0.6765
p.E631V	HCT-116	large intestine	COSMIC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation blocking phosphorylation signal	0.7222
p.V806I	BL-41	haematopoietic and lymphoid tissue	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation altering degron motif	0.7076
p.A854V	LIM1215	large intestine	COSMIC	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation blocking phosphorylation signal	0.7222
p.K809N	SNU-81	large intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation blocking phosphorylation signal	0.75
p.K809N	SNU-81	large intestine	COSMIC	MIVHDD	LIG_APCC_ABBA_1	815:820	Mutation blocking phosphorylation signal	0.6111
p.V867L	Daudi	haematopoietic and lymphoid tissue	COSMIC	FTPFID	LIG_APCC_ABBA_1	856:861	Mutation rewiring degron network	0.1667
p.E801V	HCT-116	large intestine	COSMIC	NLSNGE	DEG_Kelch_Keap1_1	803:808	Mutation blocking phosphorylation signal	0.7222
p.S712T	C3A	liver	COSMIC	VRSSS	DEG_SPOP_SBC_1	706:710	Mutation blocking phosphorylation signal	0.7222
p.K639E	KMRC-1	kidney	COSMIC	VRTTS	DEG_SPOP_SBC_1	625:629	Mutation blocking phosphorylation signal	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP4K4

UniProt ID: O95819

Entrez ID: 9448

Protein name: Mitogen-activated protein kinase kinase kinase kinase 4 (EC 2.7.11.1) (HPK/GCK-like kinase HGK) (MAPK/ERK kinase kinase kinase 4) (MEK kinase kinase 4) (MEKKK 4) (Nck-interacting kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP4K4 in