DegronMD

Uniprot ID: O95819

Source protein: Mitogen-activated protein kinase kinase kinase kinase 4

Source gene: MAP4K4

Class: DEG_SPOP_SBC_1

Location: 625:629

E3 ligase: SPOP

DEGRON score: 0.9834

ASA_SCORE: 96.76

COIL: 0.9368

CONS_SCORE: 0.3153

DSS_SCORE: 0.7367

HELIX: 0.0212

FCONS_SCORE: 1.0026

RIG_SCORE: 0.6666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A619T	TCGA-AJ-A3EK	UCEC	TCGA	VRTTS	DEG_SPOP_SBC_1	0.1667
p.A619T	DO41584	UCEC	ICGC	VRTTS	DEG_SPOP_SBC_1	0.1667
p.V623L	DO44097	BLCA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.2778
p.E635K	DO234203	ESAD	ICGC	VRTTS	DEG_SPOP_SBC_1	0.1667
p.S636F	DO234373	ESAD	ICGC	VRTTS	DEG_SPOP_SBC_1	0.1389
p.E627G	DO233276	GACA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.7199
p.A629S	DO229031	LICA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.7588
p.A629S	DO229035	LICA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.7588
p.M618I	DO23444	LINC	ICGC	VRTTS	DEG_SPOP_SBC_1	0.1389
p.T631A	DO37814	SKCM	ICGC	VRTTS	DEG_SPOP_SBC_1	0.7222
p.P632Q	DO37450	SKCM	ICGC	VRTTS	DEG_SPOP_SBC_1	0.25
p.N634S	DO38344	STAD	ICGC	VRTTS	DEG_SPOP_SBC_1	0.1944
p.V620A	DO229259	THCA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.1944
p.A629T	DO229253	THCA	ICGC	VRTTS	DEG_SPOP_SBC_1	0.7139
p.L638I	DO43186	UCEC	ICGC	VRTTS	DEG_SPOP_SBC_1	0.0833
p.Q619E	SIDM00789	Colorectal Carcinoma	GDSC	VRTTS	DEG_SPOP_SBC_1	0.1667
p.Q619E	HCT-15	large_intestine	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.1667
p.R626T	ACH-000710	Lung Cancer	CCLE	VRTTS	DEG_SPOP_SBC_1	0.6765
p.E628G	ACH-000946	Endometrial/Uterine Cancer	CCLE	VRTTS	DEG_SPOP_SBC_1	0.7199
p.T621K	Ca9-22	upper_aerodigestive_tract	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.2222
p.S635T	C3A	liver	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.1667
p.S627T	C3A	liver	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.7116
p.V636I	BL-41	haematopoietic_and_lymphoid_tissue	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.1389
p.E637V	HCT-116	large_intestine	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.1111
p.V627E	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.7693
p.E631V	HCT-116	large_intestine	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.7222
p.K639E	KMRC-1	kidney	COSMIC	VRTTS	DEG_SPOP_SBC_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	DEG_SPOP_SBC_1	625:629	VRTTS	SPOP	0.9834	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7603:7607	VRTTS	SPOP	0.8942	More...
Q86VP3	Phosphofurin acidic cluster sorting protein 2	DEG_SPOP_SBC_1	240:244	VRTTS	SPOP	0.9252	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRTTS

Degron related mutations and impact score

Drug responses associated with MAP4K4 mutations

All proteins holding degron of VRTTS