DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VRTTS
Uniprot ID:
Q7Z5P9
Source protein:
Mucin-19
Source gene:
MUC19
Class:
DEG_SPOP_SBC_1
Location:
7603:7607
E3 ligase:
SPOP
DEGRON score:
0.8942
ASA_SCORE:
94.08
COIL:
0.7878
CONS_SCORE:
0
DSS_SCORE:
0.6072
HELIX:
0.0172
FCONS_SCORE:
0
RIG_SCORE:
0.7341
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MUC19 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VRTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95819
Mitogen-activated protein kinase kinase kinase kinase 4
DEG_SPOP_SBC_1
625:629
VRTTS
SPOP
0.9834
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
7603:7607
VRTTS
SPOP
0.8942
More...
Q86VP3
Phosphofurin acidic cluster sorting protein 2
DEG_SPOP_SBC_1
240:244
VRTTS
SPOP
0.9252
More...