DegronMD - Q7Z5P9(MUC19)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T3477K	DO225032	BRCA	ICGC	AGTTT	DEG_SPOP_SBC_1	3464:3468	Mutation rewiring degron network	0.0833
p.K451I	DO225343	BRCA	ICGC	VTSSS	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.1944
p.S3461L	DO6144	BRCA	ICGC	AGTTT	DEG_SPOP_SBC_1	3464:3468	Mutation rewiring degron network	0.25
p.P1954Q	DO229387	BTCA	ICGC	PGSST	DEG_SPOP_SBC_1	1949:1953	Mutation rewiring degron network	0.3056
p.G2998E	DO229370	BTCA	ICGC	AKTTS	DEG_SPOP_SBC_1	2997:3001	Mutation altering degron motif	0.7199
p.G3476E	DO222585	COCA	ICGC	AGTTT	DEG_SPOP_SBC_1	3464:3468	Mutation rewiring degron network	0.1111
p.V1960G	DO10858	ESAD	ICGC	PGSST	DEG_SPOP_SBC_1	1949:1953	Mutation rewiring degron network	0.1389
p.P1944S	DO234163	ESAD	ICGC	PGSST	DEG_SPOP_SBC_1	1949:1953	Mutation rewiring degron network	0.1944
p.H446D	DO234168	ESAD	ICGC	VTSSS	DEG_SPOP_SBC_1	442:446	Mutation altering degron motif	0.7688
p.L426R	DO234323	ESAD	ICGC	DSGGNT	DEG_SCF_TRCP1_1	425:430	Mutation altering degron motif	0.8428
p.L426R	DO233248	GACA	ICGC	DSGGNT	DEG_SCF_TRCP1_1	425:430	Mutation altering degron motif	0.8428
p.G3005V	DO234323	ESAD	ICGC	AKTTS	DEG_SPOP_SBC_1	2997:3001	Mutation rewiring degron network	0.2222
p.A2996V	DO234285	ESAD	ICGC	AKTTS	DEG_SPOP_SBC_1	2997:3001	Mutation rewiring degron network	0.3056
p.D428Y	DO218030	GACA	ICGC	DSGGNT	DEG_SCF_TRCP1_1	425:430	Mutation altering degron motif	0.7325
p.R3114G	DO218136	GACA	ICGC	AGTSS	DEG_SPOP_SBC_1	3117:3121	Mutation rewiring degron network	0.25
p.V3474L	DO218136	GACA	ICGC	AGTTT	DEG_SPOP_SBC_1	3464:3468	Mutation rewiring degron network	0.1667
p.A473E	DO233072	GACA	ICGC	PEATPKYS	DEG_SCF_FBW7_1	464:471	Mutation rewiring degron network	0.2778
p.A473E	ACH-000975	Lung Cancer	CCLE	PEATPKYS	DEG_SCF_FBW7_1	464:471	Mutation rewiring degron network	0.2778
p.A1962T	DO230659	LAML	ICGC	PGSST	DEG_SPOP_SBC_1	1949:1953	Mutation rewiring degron network	0.0833
p.A3464V	DO230659	LAML	ICGC	AGTTT	DEG_SPOP_SBC_1	3464:3468	Mutation altering degron motif	0.5825
p.P3472A	DO230659	LAML	ICGC	AGTTT	DEG_SPOP_SBC_1	3464:3468	Mutation rewiring degron network	0.2222
p.P2992L	DO228846	LICA	ICGC	AKTTS	DEG_SPOP_SBC_1	2997:3001	Mutation rewiring degron network	0.1944
p.C462F	DO229036	LICA	ICGC	PEATPKYS	DEG_SCF_FBW7_1	464:471	Mutation rewiring degron network	0.2778
p.E447G	DO23380	LINC	ICGC	VTSSS	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.3056
p.V1690A	DO45039	LINC	ICGC	AITTS	DEG_SPOP_SBC_1	1677:1681	Mutation rewiring degron network	0.0833
p.A3165P	DO45187	LIRI	ICGC	VTVTPRQS	DEG_SCF_FBW7_1	3163:3170	Mutation altering degron motif	0.7503
p.G3001V	DO24307	LUAD	ICGC	AKTTS	DEG_SPOP_SBC_1	2997:3001	Mutation altering degron motif	0.7532
p.Y445N	DO27636	LUSC	ICGC	VTSSS	DEG_SPOP_SBC_1	442:446	Mutation altering degron motif	0.7059
p.S3111P	DO27853	MALY	ICGC	AGTSS	DEG_SPOP_SBC_1	3117:3121	Mutation rewiring degron network	0.1667
p.G3117E	DO220878	MELA	ICGC	AGTSS	DEG_SPOP_SBC_1	3117:3121	Mutation altering degron motif	0.7199
p.G3117E	DO220913	MELA	ICGC	AGTSS	DEG_SPOP_SBC_1	3117:3121	Mutation altering degron motif	0.7199
p.K415N	DO220877	MELA	ICGC	DSGGNT	DEG_SCF_TRCP1_1	425:430	Mutation rewiring degron network	0.0556
p.V3454M	DO220892	MELA	ICGC	AGTTT	DEG_SPOP_SBC_1	3464:3468	Mutation rewiring degron network	0.0556
p.G1671R	DO220908	MELA	ICGC	AITTS	DEG_SPOP_SBC_1	1677:1681	Mutation rewiring degron network	0.1667
p.G1674E	DO222363	MELA	ICGC	AITTS	DEG_SPOP_SBC_1	1677:1681	Mutation rewiring degron network	0.25
p.G3167R	DO222647	MELA	ICGC	VTVTPRQS	DEG_SCF_FBW7_1	3163:3170	Mutation altering degron motif	0.7568
p.G1978E	DO222875	MELA	ICGC	AASTT	DEG_SPOP_SBC_1	1974:1978	Mutation altering degron motif	0.7199
p.G1978E	DO229502	SKCA	ICGC	AASTT	DEG_SPOP_SBC_1	1974:1978	Mutation altering degron motif	0.7199
p.V3125G	DO218180	ORCA	ICGC	AGTSS	DEG_SPOP_SBC_1	3117:3121	Mutation blocking phosphorylation signal	0.6667
p.T3159N	DO46342	OV	ICGC	VTVTPRQS	DEG_SCF_FBW7_1	3163:3170	Mutation rewiring degron network	0.2222
p.T3156A	DO232761	PBCA	ICGC	VTVTPRQS	DEG_SCF_FBW7_1	3163:3170	Mutation rewiring degron network	0.1389
p.P438Q	DO228567	PRAD	ICGC	DSGGNT	DEG_SCF_TRCP1_1	425:430	Mutation rewiring degron network	0.1111
p.P438Q	DO228567	PRAD	ICGC	VTSSS	DEG_SPOP_SBC_1	442:446	Mutation rewiring degron network	0.2222
p.K443T	DO229459	SKCA	ICGC	VTSSS	DEG_SPOP_SBC_1	442:446	Mutation altering degron motif	0.7306
p.P444S	DO229462	SKCA	ICGC	VTSSS	DEG_SPOP_SBC_1	442:446	Mutation altering degron motif	0.6752
p.G1950R	DO218863	SKCA	ICGC	PGSST	DEG_SPOP_SBC_1	1949:1953	Mutation altering degron motif	0.6457
p.S1668L	DO37440	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	1677:1681	Mutation rewiring degron network	0.0833
p.G3466W	DO42825	UCEC	ICGC	AGTTT	DEG_SPOP_SBC_1	3464:3468	Mutation altering degron motif	0.7825
p.V3175M	ACH-000030	Lung Cancer	CCLE	VTVTPRQS	DEG_SCF_FBW7_1	3163:3170	Mutation rewiring degron network	0.1944
p.G2988R	ACH-000219	Skin Cancer	CCLE	AKTTS	DEG_SPOP_SBC_1	2997:3001	Mutation rewiring degron network	0.0833
p.V1963I	ACH-000355	Lung Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	1949:1953	Mutation rewiring degron network	0.0556
p.Y445H	ACH-000436	Myeloma	CCLE	VTSSS	DEG_SPOP_SBC_1	442:446	Mutation altering degron motif	0.7229
p.G3180A	ACH-000867	Lung Cancer	CCLE	VTVTPRQS	DEG_SCF_FBW7_1	3163:3170	Mutation rewiring degron network	0.0556
p.A1961S	ACH-000890	Lung Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	1949:1953	Mutation rewiring degron network	0.1111
p.D428E	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGGNT	DEG_SCF_TRCP1_1	425:430	Mutation altering degron motif	0.6758

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MUC19

UniProt ID: Q7Z5P9

Entrez ID: 283463

Protein name: Mucin-19 (MUC-19)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MUC19 in