DegronMD

Uniprot ID: Q7Z5P9

Source protein: Mucin-19

Source gene: MUC19

Class: DEG_SPOP_SBC_1

Location: 1677:1681

E3 ligase: SPOP

DEGRON score: 0.7646

ASA_SCORE: 66.24

COIL: 0.583

CONS_SCORE: 0.3085

DSS_SCORE: 0.5368

HELIX: 0.0204

FCONS_SCORE: 1

RIG_SCORE: 0.7315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1690A	DO45039	LINC	ICGC	AITTS	DEG_SPOP_SBC_1	0.0833
p.G1671R	DO220908	MELA	ICGC	AITTS	DEG_SPOP_SBC_1	0.1667
p.G1674E	DO222363	MELA	ICGC	AITTS	DEG_SPOP_SBC_1	0.25
p.S1668L	DO37440	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	53:57	AITTS	SPOP	0.5293	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1677:1681	AITTS	SPOP	0.7646	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2600:2604	AITTS	SPOP	0.8616	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	171:175	AITTS	SPOP	0.8729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons