DegronMD

Uniprot ID: Q9NSC2

Source protein: Sal-like protein 1

Source gene: SALL1

Class: DEG_SPOP_SBC_1

Location: 171:175

E3 ligase: SPOP

DEGRON score: 0.8729

ASA_SCORE: 78.58

COIL: 0.6554

CONS_SCORE: 0.2897

DSS_SCORE: 0.4422

HELIX: 0.0134

FCONS_SCORE: 0.9226

RIG_SCORE: 0.7449

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T173A	DO233154	GACA	ICGC	AITTS	DEG_SPOP_SBC_1	0.7139
p.A171V	TCGA-56-8308	LUSC	TCGA	AITTS	DEG_SPOP_SBC_1	0.5825
p.A171V	TCGA-A5-A0G2	UCEC	TCGA	AITTS	DEG_SPOP_SBC_1	0.5825
p.A171V	TCGA-CD-A4MG	STAD	TCGA	AITTS	DEG_SPOP_SBC_1	0.5825
p.A171V	TCGA-FI-A2D0	UCEC	TCGA	AITTS	DEG_SPOP_SBC_1	0.5825
p.A171V	DO219140	LUSC	ICGC	AITTS	DEG_SPOP_SBC_1	0.5825
p.A171V	DO48009	STAD	ICGC	AITTS	DEG_SPOP_SBC_1	0.5825
p.A171V	DO41235	UCEC	ICGC	AITTS	DEG_SPOP_SBC_1	0.5825
p.A171V	DO43891	UCEC	ICGC	AITTS	DEG_SPOP_SBC_1	0.5825
p.Q178E	TCGA-ZJ-AAXU	CESC	TCGA	AITTS	DEG_SPOP_SBC_1	0.25
p.Q178E	DO219759	CESC	ICGC	AITTS	DEG_SPOP_SBC_1	0.25
p.S166F	TCGA-86-8278	LUAD	TCGA	AITTS	DEG_SPOP_SBC_1	0.1944
p.S166F	DO26308	LUAD	ICGC	AITTS	DEG_SPOP_SBC_1	0.1944
p.S166P	DO229213	THCA	ICGC	AITTS	DEG_SPOP_SBC_1	0.1944
p.G163S	DO233861	GACA	ICGC	AITTS	DEG_SPOP_SBC_1	0.1111
p.G163S	DO229542	UTCA	ICGC	AITTS	DEG_SPOP_SBC_1	0.1111
p.G163S	SIDM01617	Endometrial Carcinoma	GDSC	AITTS	DEG_SPOP_SBC_1	0.1111
p.G163S	ACH-000994	Endometrial/Uterine Cancer	CCLE	AITTS	DEG_SPOP_SBC_1	0.1111
p.G162D	TCGA-99-7458	LUAD	TCGA	AITTS	DEG_SPOP_SBC_1	0.0833
p.G162D	DO25416	LUAD	ICGC	AITTS	DEG_SPOP_SBC_1	0.0833
p.G161S	DO222736	BTCA	ICGC	AITTS	DEG_SPOP_SBC_1	0.0556
p.G161S	SIDM00397	Acute Myeloid Leukemia	GDSC	AITTS	DEG_SPOP_SBC_1	0.0556
p.G161S	SIDM00549	B-Lymphoblastic Leukemia	GDSC	AITTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 23 of 23 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2600:2604	AITTS	SPOP	0.8616	More...
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	53:57	AITTS	SPOP	0.5293	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1677:1681	AITTS	SPOP	0.7646	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	171:175	AITTS	SPOP	0.8729	More...

Showing 1 to 4 of 4 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons