DegronMD

Uniprot ID: Q8TD26

Source protein: Chromodomain-helicase-DNA-binding protein 6

Source gene: CHD6

Class: DEG_SPOP_SBC_1

Location: 2600:2604

E3 ligase: SPOP

DEGRON score: 0.8616

ASA_SCORE: 71.22

COIL: 0.87

CONS_SCORE: 0.3701

DSS_SCORE: 0.5028

HELIX: 0.0668

FCONS_SCORE: 0.9914

RIG_SCORE: 0.6975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2592L	TCGA-BF-AAP7	SKCM	TCGA	AITTS	DEG_SPOP_SBC_1	0.1111
p.P2592L	DO219472	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	0.1111
p.P2592S	TCGA-BF-AAP7	SKCM	TCGA	AITTS	DEG_SPOP_SBC_1	0.1111
p.P2592S	DO219472	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	0.1111
p.P2590R	TCGA-DX-A6BA	SARC	TCGA	AITTS	DEG_SPOP_SBC_1	0.0556
p.P2590R	DO219995	SARC	ICGC	AITTS	DEG_SPOP_SBC_1	0.0556
p.S2594F	TCGA-EE-A3AE	SKCM	TCGA	AITTS	DEG_SPOP_SBC_1	0.1667
p.S2594F	DO37802	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	0.1667
p.L2613R	TCGA-EE-A3J4	SKCM	TCGA	AITTS	DEG_SPOP_SBC_1	0.0833
p.L2613R	DO48604	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	0.0833
p.P2599L	DO11854	GBM	ICGC	AITTS	DEG_SPOP_SBC_1	0.3056
p.T2603N	DO228952	LICA	ICGC	AITTS	DEG_SPOP_SBC_1	0.7055
p.S2604I	SIDM00282	Colorectal Carcinoma	GDSC	AITTS	DEG_SPOP_SBC_1	0.7341
p.P2599R	SIDM00225	Melanoma	GDSC	AITTS	DEG_SPOP_SBC_1	0.3056
p.P2599R	ACH-002143	Skin Cancer	CCLE	AITTS	DEG_SPOP_SBC_1	0.3056
p.P2599R	IST-MEL1	skin	COSMIC	AITTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	53:57	AITTS	SPOP	0.5293	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1677:1681	AITTS	SPOP	0.7646	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2600:2604	AITTS	SPOP	0.8616	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	171:175	AITTS	SPOP	0.8729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons