DegronMD

Uniprot ID: P15408

Source protein: Fos-related antigen 2

Source gene: FOSL2

Class: DEG_SPOP_SBC_1

Location: 53:57

E3 ligase: SPOP

DEGRON score: 0.5293

ASA_SCORE: 69.14

COIL: 0.8452

CONS_SCORE: 0.6437

DSS_SCORE: 0.285

HELIX: 0.0554

FCONS_SCORE: 0.8877

RIG_SCORE: 0.8168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S43L	TCGA-AN-A0XW	BRCA	TCGA	AITTS	DEG_SPOP_SBC_1	0.0556
p.I51V	TCGA-CN-6998	HNSC	TCGA	AITTS	DEG_SPOP_SBC_1	0.2778
p.A57T	DO233693	GACA	ICGC	AITTS	DEG_SPOP_SBC_1	0.7139
p.P53S	DO14160	HNSC	ICGC	AITTS	DEG_SPOP_SBC_1	0.6752
p.P45H	DO37798	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	0.1111
p.V63G	DO47449	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	0.1667
p.L60M	SIDM00498	Colorectal Carcinoma	GDSC	AITTS	DEG_SPOP_SBC_1	0.25
p.L60M	SNU-C5	large_intestine	COSMIC	AITTS	DEG_SPOP_SBC_1	0.25
p.S46P	ACH-000770	Leukemia	CCLE	AITTS	DEG_SPOP_SBC_1	0.1389
p.S46P	P31-FUJ	haematopoietic_and_lymphoid_tissue	COSMIC	AITTS	DEG_SPOP_SBC_1	0.1389
p.S46F	ACH-000812	Skin Cancer	CCLE	AITTS	DEG_SPOP_SBC_1	0.1389
p.S46F	COLO-783	skin	COSMIC	AITTS	DEG_SPOP_SBC_1	0.1389
p.A64T	ACH-001669	Leukemia	CCLE	AITTS	DEG_SPOP_SBC_1	0.1389
p.A64T	ACH-002238	Leukemia	CCLE	AITTS	DEG_SPOP_SBC_1	0.1389
p.A64T	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	AITTS	DEG_SPOP_SBC_1	0.1389
p.P61L	H3255	lung	COSMIC	AITTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	53:57	AITTS	SPOP	0.5293	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1677:1681	AITTS	SPOP	0.7646	More...
Q8TD26	Chromodomain-helicase-DNA-binding protein 6	DEG_SPOP_SBC_1	2600:2604	AITTS	SPOP	0.8616	More...
Q9NSC2	Sal-like protein 1	DEG_SPOP_SBC_1	171:175	AITTS	SPOP	0.8729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons