DegronMD - P15408(FOSL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R243C	TCGA-06-5416	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1111
p.P231L	TCGA-14-4157	GBM	TCGA	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7582
p.E258Q	TCGA-95-7944	LUAD	TCGA	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.0833
p.E258Q	TCGA-95-7944	LUAD	TCGA	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.S43L	TCGA-AN-A0XW	BRCA	TCGA	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.0556
p.P225A	TCGA-AX-A060	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1667
p.S244C	TCGA-BI-A0VS	CESC	TCGA	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.0833
p.I51V	TCGA-CN-6998	HNSC	TCGA	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2778
p.G257S	TCGA-D7-8574	STAD	TCGA	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.0556
p.G257S	TCGA-D7-8574	STAD	TCGA	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0833
p.K222N	TCGA-IB-7651	PAAD	TCGA	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation substituting flanking lysine	0.1944
p.K240R	TCGA-KN-8419	KICH	TCGA	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation blocking ubiquitination signal	0.6389
p.S258C	DO228331	BRCA	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.0833
p.S258C	DO228331	BRCA	ICGC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.G272R	DO227802	COCA	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation altering degron motif	0.7568
p.V234A	DO222565	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.6936
p.A57T	DO233693	GACA	ICGC	AITTS	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.7139
p.P53S	DO14160	HNSC	ICGC	AITTS	DEG_SPOP_SBC_1	53:57	Mutation altering degron motif	0.6752
p.A233S	DO228978	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.7588
p.T238S	DO220906	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.25
p.S275L	DO218958	PAAD	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.3056
p.S275L	DO218958	PAAD	ICGC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.S278F	DO229459	SKCA	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.2222
p.S278F	DO229459	SKCA	ICGC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.S278F	DO37798	SKCM	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.2222
p.S278F	DO37798	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.D277N	DO37519	SKCM	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.25
p.D277N	DO37519	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1389
p.R266S	DO37886	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7427
p.P45H	DO37798	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1111
p.V63G	DO47449	SKCM	ICGC	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1667
p.S271I	DO222387	STAD	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation altering degron motif	0.7341
p.S260A	DO43041	UCEC	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.1389
p.S260A	DO43041	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1667
p.A264V	DO41235	UCEC	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.25
p.A264V	DO41235	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.2778
p.R267I	DO42793	UCEC	ICGC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation altering degron motif	0.8102
p.R267I	DO42793	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.8102
p.A241T	SIDM00845	Burkitt's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1667
p.V266M	SIDM00680	Colorectal Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7208
p.V266M	SIDM00795	Melanoma	GDSC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7208
p.V266M	A375	skin	COSMIC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7208
p.V266M	LS-180	large intestine	COSMIC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7208
p.D239E	SIDM00834	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.2222
p.G276D	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.2778
p.G276D	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1667
p.G276D	NCI-H520	lung	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.2778
p.G276D	NCI-H520	lung	COSMIC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1667
p.L226M	SIDM00596	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1944
p.L226M	HEC-1	endometrium	COSMIC	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1944
p.R243H	SIDM00948	Burkitt's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1111
p.R243H	DG-75	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1111
p.L60M	SIDM00498	Colorectal Carcinoma	GDSC	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.L60M	SNU-C5	large intestine	COSMIC	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.25
p.V267A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation altering degron motif	0.6936
p.V267A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.5825
p.V267A	ACH-000920	Leukemia	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation altering degron motif	0.6936
p.V267A	ACH-000920	Leukemia	CCLE	VVTST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.5825
p.V267A	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation altering degron motif	0.6936
p.V267A	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.5825
p.V258M	ACH-000219	Skin Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.0833
p.V258M	ACH-000219	Skin Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.V258M	ACH-000934	Breast Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.0833
p.V258M	ACH-000934	Breast Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.V258M	ACH-000957	Colon/Colorectal Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.0833
p.V258M	ACH-000957	Colon/Colorectal Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.V258M	ACH-002001	Skin Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.0833
p.V258M	ACH-002001	Skin Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.V258M	ACH-002002	Skin Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.0833
p.V258M	ACH-002002	Skin Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.V258M	ACH-002003	Skin Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.0833
p.V258M	ACH-002003	Skin Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.V258M	A375	skin	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.0833
p.V258M	A375	skin	COSMIC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.V258M	LS-180	large intestine	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.0833
p.V258M	LS-180	large intestine	COSMIC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.G268D	ACH-000395	Lung Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation altering degron motif	0.7198
p.G268D	ACH-000395	Lung Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7198
p.G268D	NCI-H520	lung	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation altering degron motif	0.7198
p.G268D	NCI-H520	lung	COSMIC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.7198
p.E281Q	ACH-000503	Head and Neck Cancer	CCLE	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.1389
p.S46P	ACH-000770	Leukemia	CCLE	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1389
p.S46P	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1389
p.S46F	ACH-000812	Skin Cancer	CCLE	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1389
p.S46F	COLO-783	skin	COSMIC	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1389
p.I243V	ACH-000978	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1111
p.I243V	EN	endometrium	COSMIC	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation rewiring degron network	0.1111
p.A64T	ACH-001669	Leukemia	CCLE	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1389
p.A64T	ACH-002238	Leukemia	CCLE	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1389
p.A64T	GR-ST	haematopoietic and lymphoid tissue	COSMIC	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.1389
p.R235H	ACH-002232	Lymphoma	CCLE	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.8244
p.R235H	DG-75	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	231:235	Mutation altering degron motif	0.8244
p.V259A	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VTSTPAVT	DEG_SCF_FBW7_1	267:274	Mutation rewiring degron network	0.1111
p.V259A	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VVTST	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1389
p.P61L	H3255	lung	COSMIC	AITTS	DEG_SPOP_SBC_1	53:57	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOSL2

UniProt ID: P15408

Entrez ID: 2355

Protein name: Fos-related antigen 2 (FRA-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOSL2 in