DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
VVTST
Uniprot ID:
P15408
Source protein:
Fos-related antigen 2
Source gene:
FOSL2
Class:
DEG_SPOP_SBC_1
Location:
266:270
E3 ligase:
SPOP
DEGRON score:
0.9977
ASA_SCORE:
75.46
COIL:
0.7328
CONS_SCORE:
0.6882
DSS_SCORE:
0.4367
HELIX:
0.0116
FCONS_SCORE:
1.0884
RIG_SCORE:
0.7934
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R267I
DO42793
UCEC
ICGC
VVTST
DEG_SPOP_SBC_1
0.8102
p.R266S
DO37886
SKCM
ICGC
VVTST
DEG_SPOP_SBC_1
0.7427
p.V266M
SIDM00680
Colorectal Carcinoma
GDSC
VVTST
DEG_SPOP_SBC_1
0.7208
p.V266M
SIDM00795
Melanoma
GDSC
VVTST
DEG_SPOP_SBC_1
0.7208
p.V266M
A375
skin
COSMIC
VVTST
DEG_SPOP_SBC_1
0.7208
p.V266M
LS-180
large_intestine
COSMIC
VVTST
DEG_SPOP_SBC_1
0.7208
p.G268D
ACH-000395
Lung Cancer
CCLE
VVTST
DEG_SPOP_SBC_1
0.7198
p.G268D
NCI-H520
lung
COSMIC
VVTST
DEG_SPOP_SBC_1
0.7198
p.V267A
SIDM00958
Chronic Myelogenous Leukemia
GDSC
VVTST
DEG_SPOP_SBC_1
0.5825
p.V267A
ACH-000920
Leukemia
CCLE
VVTST
DEG_SPOP_SBC_1
0.5825
p.V267A
CML-T1
haematopoietic_and_lymphoid_tissue
COSMIC
VVTST
DEG_SPOP_SBC_1
0.5825
p.A264V
DO41235
UCEC
ICGC
VVTST
DEG_SPOP_SBC_1
0.2778
p.S275L
DO218958
PAAD
ICGC
VVTST
DEG_SPOP_SBC_1
0.1944
p.S260A
DO43041
UCEC
ICGC
VVTST
DEG_SPOP_SBC_1
0.1667
p.G276D
SIDM01130
Squamous Cell Lung Carcinoma
GDSC
VVTST
DEG_SPOP_SBC_1
0.1667
p.G276D
NCI-H520
lung
COSMIC
VVTST
DEG_SPOP_SBC_1
0.1667
p.D277N
DO37519
SKCM
ICGC
VVTST
DEG_SPOP_SBC_1
0.1389
p.V259A
CML-T1
haematopoietic_and_lymphoid_tissue
COSMIC
VVTST
DEG_SPOP_SBC_1
0.1389
p.E258Q
TCGA-95-7944
LUAD
TCGA
VVTST
DEG_SPOP_SBC_1
0.1111
p.S258C
DO228331
BRCA
ICGC
VVTST
DEG_SPOP_SBC_1
0.1111
p.S278F
DO229459
SKCA
ICGC
VVTST
DEG_SPOP_SBC_1
0.1111
p.S278F
DO37798
SKCM
ICGC
VVTST
DEG_SPOP_SBC_1
0.1111
p.V258M
ACH-000219
Skin Cancer
CCLE
VVTST
DEG_SPOP_SBC_1
0.1111
p.V258M
ACH-000934
Breast Cancer
CCLE
VVTST
DEG_SPOP_SBC_1
0.1111
p.V258M
ACH-000957
Colon/Colorectal Cancer
CCLE
VVTST
DEG_SPOP_SBC_1
0.1111
Showing 1 to 25 of 31 entries
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Drug responses associated with FOSL2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
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All proteins holding degron of VVTST
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8NFC6
Biorientation of chromosomes in cell division protein 1-like 1
DEG_SPOP_SBC_1
1870:1874
VVTST
SPOP
0.9754
More...
P25940
Collagen alpha-3
DEG_SPOP_SBC_1
306:310
VVTST
SPOP
0.9957
More...
P15408
Fos-related antigen 2
DEG_SPOP_SBC_1
266:270
VVTST
SPOP
0.9977
More...
Q9P266
Junctional protein associated with coronary artery disease
DEG_SPOP_SBC_1
1181:1185
VVTST
SPOP
0.6941
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
2546:2550
VVTST
SPOP
0.7708
More...
Q96L42
Potassium voltage-gated channel subfamily H member 8
DEG_SPOP_SBC_1
1092:1096
VVTST
SPOP
0.7903
More...
Q8WZ42
Titin
DEG_SPOP_SBC_1
15779:15783
VVTST
SPOP
0.5021
More...
Showing 1 to 7 of 7 entries
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