DegronMD

Uniprot ID: P15408

Source protein: Fos-related antigen 2

Source gene: FOSL2

Class: DEG_SPOP_SBC_1

Location: 266:270

E3 ligase: SPOP

DEGRON score: 0.9977

ASA_SCORE: 75.46

COIL: 0.7328

CONS_SCORE: 0.6882

DSS_SCORE: 0.4367

HELIX: 0.0116

FCONS_SCORE: 1.0884

RIG_SCORE: 0.7934

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E258Q	TCGA-95-7944	LUAD	TCGA	VVTST	DEG_SPOP_SBC_1	0.1111
p.G257S	TCGA-D7-8574	STAD	TCGA	VVTST	DEG_SPOP_SBC_1	0.0833
p.S258C	DO228331	BRCA	ICGC	VVTST	DEG_SPOP_SBC_1	0.1111
p.S275L	DO218958	PAAD	ICGC	VVTST	DEG_SPOP_SBC_1	0.1944
p.S278F	DO229459	SKCA	ICGC	VVTST	DEG_SPOP_SBC_1	0.1111
p.S278F	DO37798	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	0.1111
p.D277N	DO37519	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	0.1389
p.R266S	DO37886	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	0.7427
p.S260A	DO43041	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	0.1667
p.A264V	DO41235	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	0.2778
p.R267I	DO42793	UCEC	ICGC	VVTST	DEG_SPOP_SBC_1	0.8102
p.V266M	SIDM00680	Colorectal Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	0.7208
p.V266M	SIDM00795	Melanoma	GDSC	VVTST	DEG_SPOP_SBC_1	0.7208
p.V266M	A375	skin	COSMIC	VVTST	DEG_SPOP_SBC_1	0.7208
p.V266M	LS-180	large_intestine	COSMIC	VVTST	DEG_SPOP_SBC_1	0.7208
p.G276D	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	VVTST	DEG_SPOP_SBC_1	0.1667
p.G276D	NCI-H520	lung	COSMIC	VVTST	DEG_SPOP_SBC_1	0.1667
p.V267A	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VVTST	DEG_SPOP_SBC_1	0.5825
p.V267A	ACH-000920	Leukemia	CCLE	VVTST	DEG_SPOP_SBC_1	0.5825
p.V267A	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VVTST	DEG_SPOP_SBC_1	0.5825
p.V258M	ACH-000219	Skin Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	0.1111
p.V258M	ACH-000934	Breast Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	0.1111
p.V258M	ACH-000957	Colon/Colorectal Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	0.1111
p.V258M	ACH-002001	Skin Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	0.1111
p.V258M	ACH-002002	Skin Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	0.1111
p.V258M	ACH-002003	Skin Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	0.1111
p.V258M	A375	skin	COSMIC	VVTST	DEG_SPOP_SBC_1	0.1111
p.V258M	LS-180	large_intestine	COSMIC	VVTST	DEG_SPOP_SBC_1	0.1111
p.G268D	ACH-000395	Lung Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	0.7198
p.G268D	NCI-H520	lung	COSMIC	VVTST	DEG_SPOP_SBC_1	0.7198
p.V259A	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VVTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P15408	Fos-related antigen 2	DEG_SPOP_SBC_1	266:270	VVTST	SPOP	0.9977	More...
P25940	Collagen alpha-3	DEG_SPOP_SBC_1	306:310	VVTST	SPOP	0.9957	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2546:2550	VVTST	SPOP	0.7708	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1870:1874	VVTST	SPOP	0.9754	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	15779:15783	VVTST	SPOP	0.5021	More...
Q96L42	Potassium voltage-gated channel subfamily H member 8	DEG_SPOP_SBC_1	1092:1096	VVTST	SPOP	0.7903	More...
Q9P266	Junctional protein associated with coronary artery disease	DEG_SPOP_SBC_1	1181:1185	VVTST	SPOP	0.6941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVTST

Degron related mutations and impact score

Drug responses associated with FOSL2 mutations

All proteins holding degron of VVTST