DegronMD - Q8NFC6(BOD1L1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1783G	TCGA-05-4382	LUAD	TCGA	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation rewiring degron network	0.1389
p.D1783G	DO24900	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation rewiring degron network	0.1389
p.E1087K	TCGA-43-7656	LUSC	TCGA	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.1389
p.E1087K	DO26424	LUSC	ICGC	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.1389
p.D1869Y	TCGA-55-8299	LUAD	TCGA	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation rewiring degron network	0.3056
p.D1869Y	DO25927	LUAD	ICGC	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation rewiring degron network	0.3056
p.E1879K	TCGA-66-2768	LUSC	TCGA	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation rewiring degron network	0.1944
p.E1879K	DO50970	LICA	ICGC	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation rewiring degron network	0.1944
p.E1879K	DO27216	LUSC	ICGC	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation rewiring degron network	0.1944
p.G1109R	TCGA-73-4666	LUAD	TCGA	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.0833
p.G1109R	DO26230	LUAD	ICGC	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.0833
p.G1085V	TCGA-75-5125	LUAD	TCGA	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.0833
p.G1085V	DO24477	LUAD	ICGC	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.0833
p.Q1103H	TCGA-93-8067	LUAD	TCGA	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.25
p.Q1103H	DO25113	LUAD	ICGC	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.25
p.G1881V	TCGA-99-AA5R	LUAD	TCGA	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation rewiring degron network	0.1389
p.G1881V	DO51203	LUAD	ICGC	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation rewiring degron network	0.1389
p.E2820D	TCGA-A5-A0G2	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation rewiring degron network	0.2778
p.E2820D	DO41235	UCEC	ICGC	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation rewiring degron network	0.2778
p.L2821S	TCGA-AA-3510	COAD	TCGA	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation rewiring degron network	0.3056
p.L2821S	DO7783	COAD	ICGC	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation rewiring degron network	0.3056
p.D180G	TCGA-AA-3715	COAD	TCGA	VPTPGPS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.1111
p.D180G	DO8018	COAD	ICGC	VPTPGPS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.1111
p.D1408G	TCGA-AA-3811	COAD	TCGA	KKEND	DEG_APCC_KENBOX_2	1411:1415	Mutation rewiring degron network	0.25
p.D1408G	DO7962	COAD	ICGC	KKEND	DEG_APCC_KENBOX_2	1411:1415	Mutation rewiring degron network	0.25
p.S2826Y	TCGA-AP-A1DV	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation altering degron motif	0.712
p.S2826Y	DO43186	UCEC	ICGC	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation altering degron motif	0.712
p.S1780Y	TCGA-AX-A0J0	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation rewiring degron network	0.0556
p.S1780Y	DO41133	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation rewiring degron network	0.0556
p.T1794M	TCGA-AX-A2HD	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation altering degron motif	0.7423
p.T1794M	DO42608	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation altering degron motif	0.7423
p.K1107N	TCGA-C8-A12Q	BRCA	TCGA	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation substituting flanking lysine	0.25
p.K1107N	DO3182	BRCA	ICGC	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation substituting flanking lysine	0.25
p.T1507I	TCGA-CK-6746	COAD	TCGA	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation blocking phosphorylation signal	0.5
p.T1507I	DO7938	COAD	ICGC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation blocking phosphorylation signal	0.5
p.P1532S	TCGA-D3-A8GL	SKCM	TCGA	PATTT	DEG_SPOP_SBC_1	1537:1541	Mutation rewiring degron network	0.1944
p.P1532S	DO50287	SKCM	ICGC	PATTT	DEG_SPOP_SBC_1	1537:1541	Mutation rewiring degron network	0.1944
p.T1521A	TCGA-DI-A1BU	UCEC	TCGA	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation altering degron motif	0.7139
p.T1521A	DO42023	UCEC	ICGC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation altering degron motif	0.7139
p.G1867R	TCGA-EE-A2GJ	SKCM	TCGA	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation rewiring degron network	0.25
p.G1867R	DO37746	SKCM	ICGC	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation rewiring degron network	0.25
p.A1551V	TCGA-FI-A2D5	UCEC	TCGA	PATTT	DEG_SPOP_SBC_1	1537:1541	Mutation rewiring degron network	0.0556
p.A1551V	DO41331	UCEC	ICGC	PATTT	DEG_SPOP_SBC_1	1537:1541	Mutation rewiring degron network	0.0556
p.D1415N	TCGA-IE-A4EI	SARC	TCGA	KKEND	DEG_APCC_KENBOX_2	1411:1415	Mutation altering degron motif	0.5821
p.D1415N	DO220153	SARC	ICGC	KKEND	DEG_APCC_KENBOX_2	1411:1415	Mutation altering degron motif	0.5821
p.D1783N	TCGA-XF-A9T8	BLCA	TCGA	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation rewiring degron network	0.1389
p.D1783N	DO51927	BLCA	ICGC	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation rewiring degron network	0.1389
p.S1873N	TCGA-ZF-A9RM	BLCA	TCGA	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation altering degron motif	0.7069
p.S1873N	DO219079	BLCA	ICGC	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation altering degron motif	0.7069
p.S203L	DO10172	COAD	ICGC	VPTPGPS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.0833
p.K1412T	DO233951	GACA	ICGC	KKEND	DEG_APCC_KENBOX_2	1411:1415	Mutation altering degron motif	0.7306
p.S2830R	DO228912	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation rewiring degron network	0.2222
p.S2830R	DO229027	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation rewiring degron network	0.2222
p.T185K	DO229019	LICA	ICGC	VPTPGPS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.25
p.A1091E	DO229015	LICA	ICGC	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.25
p.Q1103K	DO229022	LICA	ICGC	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.25
p.A1512E	DO229038	LICA	ICGC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.1944
p.N2829I	DO231622	LINC	ICGC	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation rewiring degron network	0.25
p.R1511I	DO35098	PACA	ICGC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.1667
p.T1515A	SIDM00212	Glioblastoma	GDSC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2778
p.T1515A	SIDM00855	Other Sarcomas	GDSC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2778
p.T1515A	SIDM00846	Cervical Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2778
p.T1515A	SIDM00690	Head and Neck Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2778
p.T1515A	SIDM01039	Other Solid Cancers	GDSC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2778
p.T1515A	SIDM00346	Chronic Myelogenous Leukemia	GDSC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2778
p.T1515A	SIDM00493	Other Solid Cancers	GDSC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2778
p.T1515A	SIDM00844	Burkitt's Lymphoma	GDSC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2778
p.T1515A	SIDM00721	Small Cell Lung Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2778
p.T1515A	SIDM00628	Breast Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2778
p.S1108T	SIDM00934	Pancreatic Carcinoma	GDSC	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.1111
p.D1525E	SIDM00208	Glioblastoma	GDSC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2222
p.D1525E	D-502MG	central nervous system	COSMIC	VATST	DEG_SPOP_SBC_1	1517:1521	Mutation rewiring degron network	0.2222
p.P1803Q	SIDM01220	Glioma	GDSC	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation rewiring degron network	0.0833
p.P1803Q	ACH-002269	Brain Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation rewiring degron network	0.0833
p.P1803Q	LNZTA3WT4	central nervous system	COSMIC	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation rewiring degron network	0.0833
p.T2831A	SIDM00537	Colorectal Carcinoma	GDSC	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation rewiring degron network	0.1944
p.T2831A	ACH-001345	Colon/Colorectal Cancer	CCLE	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation rewiring degron network	0.1944
p.T2831A	GP5d	large intestine	COSMIC	PKTSS	DEG_SPOP_SBC_1	2822:2826	Mutation rewiring degron network	0.1944
p.A1091V	SIDM00217	Colorectal Carcinoma	GDSC	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.25
p.A1091V	ACH-000999	Colon/Colorectal Cancer	CCLE	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.25
p.A1091V	SNU-1040	large intestine	COSMIC	LSTPSGS	DEG_SCF_FBW7_1	1094:1100	Mutation rewiring degron network	0.25
p.E1786G	ACH-000982	Colon/Colorectal Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	1790:1794	Mutation rewiring degron network	0.2222
p.G1404C	ACH-001456	Colon/Colorectal Cancer	CCLE	KKEND	DEG_APCC_KENBOX_2	1411:1415	Mutation rewiring degron network	0.1389
p.T1872S	ACH-001853	Bile Duct Cancer	CCLE	VVTST	DEG_SPOP_SBC_1	1870:1874	Mutation altering degron motif	0.6005
p.N199S	ACH-001991	Primary	CCLE	VPTPGPS	DEG_SCF_FBW7_1	188:194	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BOD1L1

UniProt ID: Q8NFC6

Entrez ID: 259282

Protein name: Biorientation of chromosomes in cell division protein 1-like 1

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for BOD1L1 in