DegronMD

Uniprot ID: Q8NFC6

Source protein: Biorientation of chromosomes in cell division protein 1-like 1

Source gene: BOD1L1

Class: DEG_SPOP_SBC_1

Location: 2822:2826

E3 ligase: SPOP

DEGRON score: 0.9052

ASA_SCORE: 101.76

COIL: 0.911

CONS_SCORE: 0.3992

DSS_SCORE: 0.7308

HELIX: 0.0602

FCONS_SCORE: 0.8911

RIG_SCORE: 0.6028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2820D	TCGA-A5-A0G2	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	0.2778
p.E2820D	DO41235	UCEC	ICGC	PKTSS	DEG_SPOP_SBC_1	0.2778
p.L2821S	TCGA-AA-3510	COAD	TCGA	PKTSS	DEG_SPOP_SBC_1	0.3056
p.L2821S	DO7783	COAD	ICGC	PKTSS	DEG_SPOP_SBC_1	0.3056
p.S2826Y	TCGA-AP-A1DV	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	0.712
p.S2826Y	DO43186	UCEC	ICGC	PKTSS	DEG_SPOP_SBC_1	0.712
p.S2830R	DO228912	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.2222
p.S2830R	DO229027	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.2222
p.N2829I	DO231622	LINC	ICGC	PKTSS	DEG_SPOP_SBC_1	0.25
p.T2831A	SIDM00537	Colorectal Carcinoma	GDSC	PKTSS	DEG_SPOP_SBC_1	0.1944
p.T2831A	ACH-001345	Colon/Colorectal Cancer	CCLE	PKTSS	DEG_SPOP_SBC_1	0.1944
p.T2831A	GP5d	large_intestine	COSMIC	PKTSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43303	Centriolar coiled-coil protein of 110 kDa	DEG_SPOP_SBC_1	188:192	PKTSS	SPOP	0.6385	More...
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	489:493	PKTSS	SPOP	0.8197	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	610:614	PKTSS	SPOP	0.8762	More...
Q6ZT12	E3 ubiquitin-protein ligase UBR3	DEG_SPOP_SBC_1	1063:1067	PKTSS	SPOP	0.955	More...
Q6ZWJ1	Syntaxin-binding protein 4	DEG_SPOP_SBC_1	149:153	PKTSS	SPOP	0.8731	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	2822:2826	PKTSS	SPOP	0.9052	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	3053:3057	PKTSS	SPOP	0.8531	More...
Q96GS4	BLOC-1-related complex subunit 6	DEG_SPOP_SBC_1	62:66	PKTSS	SPOP	0.9347	More...
Q9BX26	Synaptonemal complex protein 2	DEG_SPOP_SBC_1	1141:1145	PKTSS	SPOP	0.958	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1292:1296	PKTSS	SPOP	0.6269	More...
Q9Y6B7	AP-4 complex subunit beta-1	DEG_SPOP_SBC_1	589:593	PKTSS	SPOP	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons