DegronMD

Uniprot ID: O43314

Source protein: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

Source gene: PPIP5K2

Class: DEG_SPOP_SBC_1

Location: 489:493

E3 ligase: SPOP

DEGRON score: 0.8197

ASA_SCORE: 81.62

COIL: 0.8604

CONS_SCORE: 0.266

DSS_SCORE: 0.5573

HELIX: 0.0974

FCONS_SCORE: 0.6389

RIG_SCORE: 0.6694

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L481F	TCGA-17-Z026	LUAD	TCGA	PKTSS	DEG_SPOP_SBC_1	0.1111
p.S498N	TCGA-19-5956	GBM	TCGA	PKTSS	DEG_SPOP_SBC_1	0.6389
p.S498N	DO13863	GBM	ICGC	PKTSS	DEG_SPOP_SBC_1	0.6389
p.G487D	TCGA-A5-A0G2	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	0.2778
p.G487D	DO41235	UCEC	ICGC	PKTSS	DEG_SPOP_SBC_1	0.2778
p.R499Q	TCGA-AP-A0LM	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	0.1667
p.R499Q	DO43306	UCEC	ICGC	PKTSS	DEG_SPOP_SBC_1	0.1667
p.E495D	TCGA-DK-A2I1	BLCA	TCGA	PKTSS	DEG_SPOP_SBC_1	0.2778
p.E495D	DO444	BLCA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.2778
p.S492A	DO234454	BPLL	ICGC	PKTSS	DEG_SPOP_SBC_1	0.7588
p.S492Y	DO233035	GACA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.712
p.E494G	DO228650	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.3056
p.G487V	DO228971	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.2778
p.D497G	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PKTSS	DEG_SPOP_SBC_1	0.2222
p.D497G	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PKTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43303	Centriolar coiled-coil protein of 110 kDa	DEG_SPOP_SBC_1	188:192	PKTSS	SPOP	0.6385	More...
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	489:493	PKTSS	SPOP	0.8197	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	610:614	PKTSS	SPOP	0.8762	More...
Q6ZT12	E3 ubiquitin-protein ligase UBR3	DEG_SPOP_SBC_1	1063:1067	PKTSS	SPOP	0.955	More...
Q6ZWJ1	Syntaxin-binding protein 4	DEG_SPOP_SBC_1	149:153	PKTSS	SPOP	0.8731	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	2822:2826	PKTSS	SPOP	0.9052	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	3053:3057	PKTSS	SPOP	0.8531	More...
Q96GS4	BLOC-1-related complex subunit 6	DEG_SPOP_SBC_1	62:66	PKTSS	SPOP	0.9347	More...
Q9BX26	Synaptonemal complex protein 2	DEG_SPOP_SBC_1	1141:1145	PKTSS	SPOP	0.958	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1292:1296	PKTSS	SPOP	0.6269	More...
Q9Y6B7	AP-4 complex subunit beta-1	DEG_SPOP_SBC_1	589:593	PKTSS	SPOP	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons