DegronMD

Uniprot ID: Q9NSI6

Source protein: Bromodomain and WD repeat-containing protein 1

Source gene: BRWD1

Class: DEG_SPOP_SBC_1

Location: 1292:1296

E3 ligase: SPOP

DEGRON score: 0.6269

ASA_SCORE: 90.2

COIL: 0.8958

CONS_SCORE: 0.2933

DSS_SCORE: 0.6179

HELIX: 0.086

FCONS_SCORE: 1.1607

RIG_SCORE: 0.6154

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1300I	TCGA-29-2434	OV	TCGA	PKTSS	DEG_SPOP_SBC_1	0.2222
p.R1300I	DO31360	OV	ICGC	PKTSS	DEG_SPOP_SBC_1	0.2222
p.D1287N	TCGA-D3-A8GP	SKCM	TCGA	PKTSS	DEG_SPOP_SBC_1	0.1944
p.D1287N	DO51244	SKCM	ICGC	PKTSS	DEG_SPOP_SBC_1	0.1944
p.S1289I	TCGA-HC-A9TE	PRAD	TCGA	PKTSS	DEG_SPOP_SBC_1	0.6944
p.S1289I	DO223658	PRAD	ICGC	PKTSS	DEG_SPOP_SBC_1	0.6944
p.T1294A	DO233292	NACA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.7139
p.G1297A	DO233297	NACA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.3056
p.S1296F	DO233299	NACA	ICGC	PKTSS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43303	Centriolar coiled-coil protein of 110 kDa	DEG_SPOP_SBC_1	188:192	PKTSS	SPOP	0.6385	More...
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	489:493	PKTSS	SPOP	0.8197	More...
Q14966	Zinc finger protein 638	DEG_SPOP_SBC_1	610:614	PKTSS	SPOP	0.8762	More...
Q6ZT12	E3 ubiquitin-protein ligase UBR3	DEG_SPOP_SBC_1	1063:1067	PKTSS	SPOP	0.955	More...
Q6ZWJ1	Syntaxin-binding protein 4	DEG_SPOP_SBC_1	149:153	PKTSS	SPOP	0.8731	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	2822:2826	PKTSS	SPOP	0.9052	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	3053:3057	PKTSS	SPOP	0.8531	More...
Q96GS4	BLOC-1-related complex subunit 6	DEG_SPOP_SBC_1	62:66	PKTSS	SPOP	0.9347	More...
Q9BX26	Synaptonemal complex protein 2	DEG_SPOP_SBC_1	1141:1145	PKTSS	SPOP	0.958	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1292:1296	PKTSS	SPOP	0.6269	More...
Q9Y6B7	AP-4 complex subunit beta-1	DEG_SPOP_SBC_1	589:593	PKTSS	SPOP	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons