DegronMD - O43314(PPIP5K2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1199L	TCGA-05-4250	LUAD	TCGA	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation blocking phosphorylation signal	0.6944
p.S1199L	DO24457	LUAD	ICGC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation blocking phosphorylation signal	0.6944
p.L481F	TCGA-17-Z026	LUAD	TCGA	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.1111
p.S498N	TCGA-19-5956	GBM	TCGA	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation blocking phosphorylation signal	0.6389
p.S498N	DO13863	GBM	ICGC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation blocking phosphorylation signal	0.6389
p.S1025N	TCGA-23-2072	OV	TCGA	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7069
p.S1025N	DO32507	OV	ICGC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7069
p.S1025I	TCGA-64-5815	LUAD	TCGA	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7341
p.S1025I	DO23578	LUAD	ICGC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7341
p.S1035Y	TCGA-77-7337	LUSC	TCGA	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.0556
p.S1035Y	DO27445	LUSC	ICGC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.0556
p.G487D	TCGA-A5-A0G2	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.2778
p.G487D	DO41235	UCEC	ICGC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.2778
p.R499Q	TCGA-AP-A0LM	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.1667
p.R499Q	DO43306	UCEC	ICGC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.1667
p.E363D	TCGA-AX-A0J0	UCEC	TCGA	VPTTS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.1389
p.E363D	DO41133	UCEC	ICGC	VPTTS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.1389
p.T1023A	TCGA-AX-A1CE	UCEC	TCGA	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7139
p.T1023A	DO42280	UCEC	ICGC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7139
p.V1136I	TCGA-B5-A11Y	UCEC	TCGA	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.0556
p.V1136I	DO40889	UCEC	ICGC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.0556
p.P1109L	TCGA-BF-A5ES	SKCM	TCGA	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.1111
p.P1109L	DO219456	SKCM	ICGC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.1111
p.S1016F	TCGA-BH-A18P	BRCA	TCGA	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation blocking phosphorylation signal	0.6389
p.S1016F	DO3346	BRCA	ICGC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation blocking phosphorylation signal	0.6389
p.L1126F	TCGA-C4-A0F1	BLCA	TCGA	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.6981
p.L1126F	DO581	BLCA	ICGC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.6981
p.Q1121K	TCGA-D7-A6F0	STAD	TCGA	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.6944
p.Q1121K	DO50120	STAD	ICGC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.6944
p.E495D	TCGA-DK-A2I1	BLCA	TCGA	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.2778
p.E495D	DO444	BLCA	ICGC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.2778
p.S1016Y	TCGA-DK-A2I2	BLCA	TCGA	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation blocking phosphorylation signal	0.6389
p.S1016Y	DO708	BLCA	ICGC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation blocking phosphorylation signal	0.6389
p.K1203N	TCGA-E6-A1LZ	UCEC	TCGA	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation rewiring degron network	0.1389
p.K1203N	DO41398	UCEC	ICGC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation rewiring degron network	0.1389
p.S374Y	TCGA-IG-A3Y9	ESCA	TCGA	VPTTS	DEG_SPOP_SBC_1	370:374	Mutation altering degron motif	0.712
p.K1221N	TCGA-ND-A4WC	UCS	TCGA	PNTSS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.6918
p.K1221N	ACH-002280	Neuroblastoma	CCLE	PNTSS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.6918
p.K1221N	NB13	autonomic ganglia	COSMIC	PNTSS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.6918
p.P1014S	TCGA-W3-AA1V	SKCM	TCGA	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.1389
p.P1014S	DO51276	SKCM	ICGC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.1389
p.S492A	DO234454	BPLL	ICGC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.7588
p.R1113Q	DO230312	COCA	ICGC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.2222
p.R1113Q	ACH-000806	Lymphoma	CCLE	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.2222
p.R1113Q	L-540	haematopoietic and lymphoid tissue	COSMIC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.2222
p.E363Q	DO10839	ESAD	ICGC	VPTTS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.1389
p.M378I	DO222789	ESCA	ICGC	VPTTS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.2222
p.S492Y	DO233035	GACA	ICGC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.712
p.E494G	DO228650	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.3056
p.L1020F	DO228948	LICA	ICGC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.3056
p.R381I	DO228976	LICA	ICGC	VPTTS	DEG_SPOP_SBC_1	370:374	Mutation rewiring degron network	0.1389
p.G487V	DO228971	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.2778
p.F1125S	DO232761	PBCA	ICGC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.7982
p.R1115H	SIDM01307	Colorectal Carcinoma	GDSC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.2778
p.A1197T	SIDM01265	Plasma Cell Myeloma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation rewiring degron network	0.3056
p.A1197T	SIDM00889	Cervical Carcinoma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation rewiring degron network	0.3056
p.A1197T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation rewiring degron network	0.3056
p.R1121W	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.8634
p.R1121W	SIDM00230	Small Cell Lung Carcinoma	GDSC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.8634
p.R1121W	NCI-H2291	lung	COSMIC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.8634
p.R1121W	IST-SL2	lung	COSMIC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.8634
p.D497G	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.2222
p.D497G	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation rewiring degron network	0.2222
p.R1205C	SIDM01078	Small Cell Lung Carcinoma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation substituting flanking lysine	0.1944
p.R1205C	SIDM00878	Breast Carcinoma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation substituting flanking lysine	0.1944
p.R1128Q	SIDM00329	Hodgkin's Lymphoma	GDSC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.2778
p.R1128Q	L-540	haematopoietic and lymphoid tissue	COSMIC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.2778
p.P1228R	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.1389
p.P1228R	NCI-H1781	lung	COSMIC	PNTSS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.1389
p.G1015R	SIDM00151	Ovarian Carcinoma	GDSC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.1667
p.P1188L	SIDM00140	Melanoma	GDSC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation rewiring degron network	0.3056
p.P1188L	COLO-792	skin	COSMIC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation rewiring degron network	0.3056
p.L1225H	SIDM01033	Bladder Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.2222
p.L1225H	KU-19-19	urinary tract	COSMIC	PNTSS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.2222
p.R1017Q	SIDM01588	Endometrial Carcinoma	GDSC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.2222
p.P1132L	ACH-000968	Skin Cancer	CCLE	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.1667
p.P1132L	COLO-792	skin	COSMIC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation rewiring degron network	0.1667
p.S1035F	ACH-001398	Kidney Cancer	CCLE	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.0556
p.S1035F	SW156	kidney	COSMIC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation rewiring degron network	0.0556
p.S1118Y	ACH-002272	Lymphoma	CCLE	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.712
p.S1118Y	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.712
p.L1190H	KU-19-19	urinary tract	COSMIC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation altering degron motif	0.6202
p.P1193R	NCI-H1781	lung	COSMIC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation altering degron motif	0.7512

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPIP5K2

UniProt ID: O43314

Entrez ID: 23262

Protein name: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPIP5K2 in