DegronMD - O43314(PPIP5K2)

FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4 (PubMed:17690096, Pu... View more >>

GO - Biological processes (BP): inositol metabolic process [GO:0006020]; inositol phosphate biosynthetic process [GO:0032958]; inositol phosphate metabolic process [GO:0043647]; sensory perception of sound [GO:0007605]

GO - Molecular function (MF): 5-diphosphoinositol pentakisphosphate 3-kinase activity [GO:0102092]; ATP binding [GO:0005524]; diphosphoinositol-pentakisphosphate kinase activity [GO:0033857]; inositol-1,3,4,5,6-pentakisphosphate kinase activity [GO:0000827]; inositol heptakisphosphate kinase activity [GO:0000829]; inositol hexak... View more >>

GO - Cellular component (CC): cytosol [GO:0005829]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Degron hit	Class	E3 ligase	Source protein	Location	Detail
NGFELYSMVP	CBL_PTK	CBL	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	1117:1126	More..
ILPTPPAT	DEG_SCF_FBW7_1	FBXW7	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	1189:1196	More..
VPTTS	DEG_SPOP_SBC_1	SPOP	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	370:374	More..
PKTSS	DEG_SPOP_SBC_1	SPOP	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	489:493	More..
AFTSS	DEG_SPOP_SBC_1	SPOP	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	1021:1025	More..
PNTSS	DEG_SPOP_SBC_1	SPOP	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	1217:1221	More..

Showing 1 to 6 of 6 entries

Previous1Next

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1121W	SIDM00728	Non-Small Cell Lung Carcinoma	GDSC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.8634
p.R1121W	SIDM00230	Small Cell Lung Carcinoma	GDSC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.8634
p.R1121W	NCI-H2291	lung	COSMIC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.8634
p.R1121W	IST-SL2	lung	COSMIC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.8634
p.F1125S	DO232761	PBCA	ICGC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.7982
p.S492A	DO234454	BPLL	ICGC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.7588
p.P1193R	NCI-H1781	lung	COSMIC	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation altering degron motif	0.7512
p.S1025I	TCGA-64-5815	LUAD	TCGA	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7341
p.S1025I	DO23578	LUAD	ICGC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7341
p.T1023A	TCGA-AX-A1CE	UCEC	TCGA	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7139
p.T1023A	DO42280	UCEC	ICGC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7139
p.S374Y	TCGA-IG-A3Y9	ESCA	TCGA	VPTTS	DEG_SPOP_SBC_1	370:374	Mutation altering degron motif	0.712
p.S492Y	DO233035	GACA	ICGC	PKTSS	DEG_SPOP_SBC_1	489:493	Mutation altering degron motif	0.712
p.S1118Y	ACH-002272	Lymphoma	CCLE	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.712
p.S1118Y	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.712
p.S1025N	TCGA-23-2072	OV	TCGA	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7069
p.S1025N	DO32507	OV	ICGC	AFTSS	DEG_SPOP_SBC_1	1021:1025	Mutation altering degron motif	0.7069
p.L1126F	TCGA-C4-A0F1	BLCA	TCGA	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.6981
p.L1126F	DO581	BLCA	ICGC	NGFELYSMVP	CBL_PTK	1117:1126	Mutation altering degron motif	0.6981
p.S1199L	TCGA-05-4250	LUAD	TCGA	ILPTPPAT	DEG_SCF_FBW7_1	1189:1196	Mutation blocking phosphorylation signal	0.6944

Showing 1 to 20 of 83 entries

Previous1 2 3 4 5Next

No resistance data available for this Degron.

Kaplan plot for PPIP5K2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPIP5K2

UniProt ID: O43314

Entrez ID: 23262

Protein name: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

No resistance data available for this Degron.

Kaplan plot for PPIP5K2 in