DegronMD

Uniprot ID: O43314

Source protein: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

Source gene: PPIP5K2

Class: DEG_SPOP_SBC_1

Location: 1021:1025

E3 ligase: SPOP

DEGRON score: 0.6303

ASA_SCORE: 64.36

COIL: 0.6654

CONS_SCORE: 0.2975

DSS_SCORE: 0.315

HELIX: 0.2022

FCONS_SCORE: 0.9631

RIG_SCORE: 0.7525

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1025N	TCGA-23-2072	OV	TCGA	AFTSS	DEG_SPOP_SBC_1	0.7069
p.S1025N	DO32507	OV	ICGC	AFTSS	DEG_SPOP_SBC_1	0.7069
p.S1025I	TCGA-64-5815	LUAD	TCGA	AFTSS	DEG_SPOP_SBC_1	0.7341
p.S1025I	DO23578	LUAD	ICGC	AFTSS	DEG_SPOP_SBC_1	0.7341
p.S1035Y	TCGA-77-7337	LUSC	TCGA	AFTSS	DEG_SPOP_SBC_1	0.0556
p.S1035Y	DO27445	LUSC	ICGC	AFTSS	DEG_SPOP_SBC_1	0.0556
p.T1023A	TCGA-AX-A1CE	UCEC	TCGA	AFTSS	DEG_SPOP_SBC_1	0.7139
p.T1023A	DO42280	UCEC	ICGC	AFTSS	DEG_SPOP_SBC_1	0.7139
p.S1016F	TCGA-BH-A18P	BRCA	TCGA	AFTSS	DEG_SPOP_SBC_1	0.6389
p.S1016F	DO3346	BRCA	ICGC	AFTSS	DEG_SPOP_SBC_1	0.6389
p.S1016Y	TCGA-DK-A2I2	BLCA	TCGA	AFTSS	DEG_SPOP_SBC_1	0.6389
p.S1016Y	DO708	BLCA	ICGC	AFTSS	DEG_SPOP_SBC_1	0.6389
p.P1014S	TCGA-W3-AA1V	SKCM	TCGA	AFTSS	DEG_SPOP_SBC_1	0.1389
p.P1014S	DO51276	SKCM	ICGC	AFTSS	DEG_SPOP_SBC_1	0.1389
p.L1020F	DO228948	LICA	ICGC	AFTSS	DEG_SPOP_SBC_1	0.3056
p.G1015R	SIDM00151	Ovarian Carcinoma	GDSC	AFTSS	DEG_SPOP_SBC_1	0.1667
p.R1017Q	SIDM01588	Endometrial Carcinoma	GDSC	AFTSS	DEG_SPOP_SBC_1	0.2222
p.S1035F	ACH-001398	Kidney Cancer	CCLE	AFTSS	DEG_SPOP_SBC_1	0.0556
p.S1035F	SW156	kidney	COSMIC	AFTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	1021:1025	AFTSS	SPOP	0.6303	More...
Q9HCK4	Roundabout homolog 2	DEG_SPOP_SBC_1	1256:1260	AFTSS	SPOP	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons