DegronMD - Q9HCK4(ROBO2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1141Y	TCGA-05-4403	LUAD	TCGA	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.0833
p.D1141Y	TCGA-R5-A7ZE	STAD	TCGA	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.0833
p.D1254E	TCGA-33-4532	LUSC	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.0556
p.D1254E	TCGA-33-4532	LUSC	TCGA	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.2778
p.E1229Q	TCGA-49-AARE	LUAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.1111
p.S1119I	TCGA-53-7624	LUAD	TCGA	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.2222
p.D1238N	TCGA-A5-A0G2	UCEC	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation altering degron motif	0.5821
p.D1254G	TCGA-A5-A0G2	UCEC	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.0556
p.D1254G	TCGA-A5-A0G2	UCEC	TCGA	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.2778
p.T1230M	TCGA-AA-A00N	COAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.1389
p.D1239N	TCGA-AA-A00N	COAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation altering degron motif	0.6932
p.D1239N	TCGA-LH-A9QB	SKCM	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation altering degron motif	0.6932
p.E1245A	TCGA-AA-A02Y	COAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.3056
p.D1254V	TCGA-B9-A69E	KIRP	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.0556
p.D1254V	TCGA-B9-A69E	KIRP	TCGA	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.2778
p.D1136H	TCGA-BA-5152	HNSC	TCGA	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.2222
p.T1128S	TCGA-BP-5180	KIRC	TCGA	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.7116
p.G1114C	TCGA-BR-4357	STAD	TCGA	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.0833
p.L1228F	TCGA-CA-6717	COAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.0833
p.Y1115C	TCGA-CC-A7IK	LIHC	TCGA	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1111
p.E1137Q	TCGA-CV-5444	HNSC	TCGA	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1944
p.P1122Q	TCGA-E8-A2EA	THCA	TCGA	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.3056
p.E1229K	TCGA-EE-A2M6	SKCM	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.1111
p.E1229K	TCGA-GN-A26C	SKCM	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.1111
p.L1250M	TCGA-ER-A2NH	SKCM	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.1667
p.L1250M	TCGA-ER-A2NH	SKCM	TCGA	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.1667
p.D1231N	TCGA-FR-A7U9	SKCM	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.1667
p.P1257S	TCGA-FW-A3R5	SKCM	TCGA	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation altering degron motif	0.6752
p.E1240K	TCGA-VQ-A8P2	STAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation altering degron motif	0.7022
p.R1264Q	DO4191	BRCA	ICGC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.2222
p.R1264Q	ACH-000364	Primary	CCLE	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.2222
p.R1264Q	U-2-OS	bone	COSMIC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.2222
p.E1229A	DO7858	COAD	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.1111
p.V1257E	DO228927	COCA	ICGC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation altering degron motif	0.7693
p.D1238G	DO222798	COCA	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation altering degron motif	0.6087
p.D1238G	DO41235	UCEC	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation altering degron motif	0.6087
p.M1256I	DO234356	ESAD	ICGC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation altering degron motif	0.7618
p.V1137A	DO234363	ESAD	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1944
p.R1268C	DO233152	GACA	ICGC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.1111
p.R1268C	ACH-001415	Bladder Cancer	CCLE	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.1111
p.E1124K	DO11854	GBM	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.591
p.E1124K	DO220890	MELA	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.591
p.E1121Q	DO14598	HNSC	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.2778
p.D1120H	DO14393	HNSC	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.25
p.G1136D	DO14173	HNSC	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.2222
p.D1238V	DO44513	KIRP	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation altering degron motif	0.6674
p.L1122V	DO228299	LICA	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.3056
p.V1257L	DO228974	LICA	ICGC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation altering degron motif	0.6765
p.A1236S	DO229028	LICA	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.3056
p.R1268L	DO229027	LICA	ICGC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.1111
p.G1136V	DO229031	LICA	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.2222
p.G1117C	DO229035	LICA	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1667
p.A1263S	DO229037	LICA	ICGC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.25
p.P1141T	DO45351	LUAD	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.0833
p.D1125Y	DO23631	LUAD	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.6214
p.D1125Y	DO222340	STAD	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.6214
p.R1135L	DO26518	LUSC	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.25
p.D1238E	DO26626	LUSC	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation altering degron motif	0.5647
p.T1131S	DO26602	LUSC	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.6005
p.G1136C	DO219129	LUSC	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.2222
p.E1123K	DO220851	MELA	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.7022
p.P1141S	DO37831	SKCM	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.0833
p.P1241S	DO37406	SKCM	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation altering degron motif	0.6752
p.D1127N	DO47368	SKCM	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.5821
p.L1234M	DO47683	SKCM	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.25
p.R1262K	DO51269	SKCM	ICGC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.2778
p.V1137M	DO48016	STAD	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1944
p.V1137M	ACH-000936	Ovarian Cancer	CCLE	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1944
p.V1137M	ACH-001674	Neuroblastoma	CCLE	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1944
p.V1137M	EFO-27	ovary	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1944
p.V1137M	TGW	autonomic ganglia	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1944
p.S1267I	DO47907	STAD	ICGC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation blocking phosphorylation signal	0.5833
p.S1267I	PF-382	haematopoietic and lymphoid tissue	COSMIC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation blocking phosphorylation signal	0.5833
p.A1138S	DO42280	UCEC	ICGC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1667
p.P1268Q	DO52412	UCEC	ICGC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.1111
p.W1260R	DO41211	UCEC	ICGC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation altering degron motif	0.8634
p.D1236Y	SIDM00477	Esophageal Carcinoma	GDSC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.3056
p.D1236Y	OE33	oesophagus	COSMIC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.3056
p.P1249L	SIDM00795	Melanoma	GDSC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.1944
p.P1249L	SIDM00795	Melanoma	GDSC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.1389
p.P1249L	A375	skin	COSMIC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.1944
p.P1249L	A375	skin	COSMIC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.1389
p.D1227Y	SIDM01218	Other Solid Cancers	GDSC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.0556
p.D1227Y	JEG-3	placenta	COSMIC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.0556
p.P1257L	SIDM00487	Colorectal Carcinoma	GDSC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation altering degron motif	0.7582
p.P1257L	CCK-81	large intestine	COSMIC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation altering degron motif	0.7582
p.V1126I	SIDM00150	Colorectal Carcinoma	GDSC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.7076
p.V1126I	KM12	large intestine	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.7076
p.P1233L	ACH-000219	Skin Cancer	CCLE	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.2222
p.P1233L	ACH-002001	Skin Cancer	CCLE	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.2222
p.P1233L	ACH-002002	Skin Cancer	CCLE	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.2222
p.P1233L	ACH-002003	Skin Cancer	CCLE	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.2222
p.P1233L	A375	skin	COSMIC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation rewiring degron network	0.2222
p.R1264P	ACH-000702	Lymphoma	CCLE	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.2222
p.R1264P	L-1236	haematopoietic and lymphoid tissue	COSMIC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.2222
p.R1128T	ACH-000888	Lung Cancer	CCLE	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.6765
p.R1128T	NCI-H1793	lung	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation altering degron motif	0.6765
p.P1241L	ACH-000963	Colon/Colorectal Cancer	CCLE	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation altering degron motif	0.7582
p.P1241L	CCK-81	large intestine	COSMIC	LDQTPGSS	DEG_SCF_FBW7_1	1237:1244	Mutation altering degron motif	0.7582
p.P1141L	ACH-001081	Colon/Colorectal Cancer	CCLE	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.0833
p.P1141L	HCC2998	large intestine	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.0833
p.G1136S	ACH-001307	Thyroid Cancer	CCLE	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.2222
p.G1136S	8505C	thyroid	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.2222
p.S1139F	ACH-002220	Lymphoma	CCLE	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1389
p.S1139F	CRO-AP2	haematopoietic and lymphoid tissue	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1389
p.S1139I	PF-382	haematopoietic and lymphoid tissue	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.1389
p.R1136Q	U-2-OS	bone	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.2222
p.R1136P	L-1236	haematopoietic and lymphoid tissue	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.2222
p.R1136L	ChaGo-K-1	lung	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.2222
p.P1113L	CCK-81	large intestine	COSMIC	EEDDDRVPTP	DEG_COP1_1	1123:1132	Mutation rewiring degron network	0.0556
p.R1264L	ChaGo-K-1	lung	COSMIC	AFTSS	DEG_SPOP_SBC_1	1256:1260	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ROBO2

UniProt ID: Q9HCK4

Entrez ID: 6092

Protein name: Roundabout homolog 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ROBO2 in