DegronMD

Uniprot ID: Q9HCK4

Source protein: Roundabout homolog 2

Source gene: ROBO2

Class: DEG_COP1_1

Location: 1123:1132

E3 ligase: COP1

DEGRON score: 0.9942

ASA_SCORE: 104.26

COIL: 0.8619

CONS_SCORE: 0.4205

DSS_SCORE: 0.7377

HELIX: 0.1367

FCONS_SCORE: 1.1637

RIG_SCORE: 0.7106

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1141Y	TCGA-05-4403	LUAD	TCGA	EEDDDRVPTP	DEG_COP1_1	0.0833
p.D1141Y	TCGA-R5-A7ZE	STAD	TCGA	EEDDDRVPTP	DEG_COP1_1	0.0833
p.S1119I	TCGA-53-7624	LUAD	TCGA	EEDDDRVPTP	DEG_COP1_1	0.2222
p.D1136H	TCGA-BA-5152	HNSC	TCGA	EEDDDRVPTP	DEG_COP1_1	0.2222
p.T1128S	TCGA-BP-5180	KIRC	TCGA	EEDDDRVPTP	DEG_COP1_1	0.7116
p.G1114C	TCGA-BR-4357	STAD	TCGA	EEDDDRVPTP	DEG_COP1_1	0.0833
p.Y1115C	TCGA-CC-A7IK	LIHC	TCGA	EEDDDRVPTP	DEG_COP1_1	0.1111
p.E1137Q	TCGA-CV-5444	HNSC	TCGA	EEDDDRVPTP	DEG_COP1_1	0.1944
p.P1122Q	TCGA-E8-A2EA	THCA	TCGA	EEDDDRVPTP	DEG_COP1_1	0.3056
p.V1137A	DO234363	ESAD	ICGC	EEDDDRVPTP	DEG_COP1_1	0.1944
p.E1124K	DO11854	GBM	ICGC	EEDDDRVPTP	DEG_COP1_1	0.591
p.E1124K	DO220890	MELA	ICGC	EEDDDRVPTP	DEG_COP1_1	0.591
p.E1121Q	DO14598	HNSC	ICGC	EEDDDRVPTP	DEG_COP1_1	0.2778
p.D1120H	DO14393	HNSC	ICGC	EEDDDRVPTP	DEG_COP1_1	0.25
p.G1136D	DO14173	HNSC	ICGC	EEDDDRVPTP	DEG_COP1_1	0.2222
p.L1122V	DO228299	LICA	ICGC	EEDDDRVPTP	DEG_COP1_1	0.3056
p.G1136V	DO229031	LICA	ICGC	EEDDDRVPTP	DEG_COP1_1	0.2222
p.G1117C	DO229035	LICA	ICGC	EEDDDRVPTP	DEG_COP1_1	0.1667
p.P1141T	DO45351	LUAD	ICGC	EEDDDRVPTP	DEG_COP1_1	0.0833
p.D1125Y	DO23631	LUAD	ICGC	EEDDDRVPTP	DEG_COP1_1	0.6214
p.D1125Y	DO222340	STAD	ICGC	EEDDDRVPTP	DEG_COP1_1	0.6214
p.R1135L	DO26518	LUSC	ICGC	EEDDDRVPTP	DEG_COP1_1	0.25
p.T1131S	DO26602	LUSC	ICGC	EEDDDRVPTP	DEG_COP1_1	0.6005
p.G1136C	DO219129	LUSC	ICGC	EEDDDRVPTP	DEG_COP1_1	0.2222
p.E1123K	DO220851	MELA	ICGC	EEDDDRVPTP	DEG_COP1_1	0.7022
p.P1141S	DO37831	SKCM	ICGC	EEDDDRVPTP	DEG_COP1_1	0.0833
p.D1127N	DO47368	SKCM	ICGC	EEDDDRVPTP	DEG_COP1_1	0.5821
p.V1137M	DO48016	STAD	ICGC	EEDDDRVPTP	DEG_COP1_1	0.1944
p.V1137M	ACH-000936	Ovarian Cancer	CCLE	EEDDDRVPTP	DEG_COP1_1	0.1944
p.V1137M	ACH-001674	Neuroblastoma	CCLE	EEDDDRVPTP	DEG_COP1_1	0.1944
p.V1137M	EFO-27	ovary	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.1944
p.V1137M	TGW	autonomic_ganglia	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.1944
p.A1138S	DO42280	UCEC	ICGC	EEDDDRVPTP	DEG_COP1_1	0.1667
p.V1126I	SIDM00150	Colorectal Carcinoma	GDSC	EEDDDRVPTP	DEG_COP1_1	0.7076
p.V1126I	KM12	large_intestine	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.7076
p.R1128T	ACH-000888	Lung Cancer	CCLE	EEDDDRVPTP	DEG_COP1_1	0.6765
p.R1128T	NCI-H1793	lung	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.6765
p.P1141L	ACH-001081	Colon/Colorectal Cancer	CCLE	EEDDDRVPTP	DEG_COP1_1	0.0833
p.P1141L	HCC2998	large_intestine	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.0833
p.G1136S	ACH-001307	Thyroid Cancer	CCLE	EEDDDRVPTP	DEG_COP1_1	0.2222
p.G1136S	8505C	thyroid	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.2222
p.S1139F	ACH-002220	Lymphoma	CCLE	EEDDDRVPTP	DEG_COP1_1	0.1389
p.S1139F	CRO-AP2	haematopoietic_and_lymphoid_tissue	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.1389
p.S1139I	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.1389
p.R1136Q	U-2-OS	bone	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.2222
p.R1136P	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.2222
p.R1136L	ChaGo-K-1	lung	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.2222
p.P1113L	CCK-81	large_intestine	COSMIC	EEDDDRVPTP	DEG_COP1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EEDDDRVPTP

Degron related mutations and impact score

Drug responses associated with ROBO2 mutations

All proteins holding degron of EEDDDRVPTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCK4	Roundabout homolog 2	DEG_COP1_1	1123:1132	EEDDDRVPTP	COP1	0.9942	More...