DegronMD

Uniprot ID: Q9HCK4

Source protein: Roundabout homolog 2

Source gene: ROBO2

Class: DEG_SPOP_SBC_1

Location: 1256:1260

E3 ligase: SPOP

DEGRON score: 0.9233

ASA_SCORE: 72.36

COIL: 0.839

CONS_SCORE: 0.2424

DSS_SCORE: 0.6876

HELIX: 0.1064

FCONS_SCORE: 0.6858

RIG_SCORE: 0.6407

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1254E	TCGA-33-4532	LUSC	TCGA	AFTSS	DEG_SPOP_SBC_1	0.2778
p.D1254G	TCGA-A5-A0G2	UCEC	TCGA	AFTSS	DEG_SPOP_SBC_1	0.2778
p.D1254V	TCGA-B9-A69E	KIRP	TCGA	AFTSS	DEG_SPOP_SBC_1	0.2778
p.L1250M	TCGA-ER-A2NH	SKCM	TCGA	AFTSS	DEG_SPOP_SBC_1	0.1667
p.P1257S	TCGA-FW-A3R5	SKCM	TCGA	AFTSS	DEG_SPOP_SBC_1	0.6752
p.R1264Q	DO4191	BRCA	ICGC	AFTSS	DEG_SPOP_SBC_1	0.2222
p.R1264Q	ACH-000364	Primary	CCLE	AFTSS	DEG_SPOP_SBC_1	0.2222
p.R1264Q	U-2-OS	bone	COSMIC	AFTSS	DEG_SPOP_SBC_1	0.2222
p.V1257E	DO228927	COCA	ICGC	AFTSS	DEG_SPOP_SBC_1	0.7693
p.M1256I	DO234356	ESAD	ICGC	AFTSS	DEG_SPOP_SBC_1	0.7618
p.R1268C	DO233152	GACA	ICGC	AFTSS	DEG_SPOP_SBC_1	0.1111
p.R1268C	ACH-001415	Bladder Cancer	CCLE	AFTSS	DEG_SPOP_SBC_1	0.1111
p.V1257L	DO228974	LICA	ICGC	AFTSS	DEG_SPOP_SBC_1	0.6765
p.R1268L	DO229027	LICA	ICGC	AFTSS	DEG_SPOP_SBC_1	0.1111
p.A1263S	DO229037	LICA	ICGC	AFTSS	DEG_SPOP_SBC_1	0.25
p.R1262K	DO51269	SKCM	ICGC	AFTSS	DEG_SPOP_SBC_1	0.2778
p.S1267I	DO47907	STAD	ICGC	AFTSS	DEG_SPOP_SBC_1	0.5833
p.S1267I	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	AFTSS	DEG_SPOP_SBC_1	0.5833
p.P1268Q	DO52412	UCEC	ICGC	AFTSS	DEG_SPOP_SBC_1	0.1111
p.W1260R	DO41211	UCEC	ICGC	AFTSS	DEG_SPOP_SBC_1	0.8634
p.P1249L	SIDM00795	Melanoma	GDSC	AFTSS	DEG_SPOP_SBC_1	0.1389
p.P1249L	A375	skin	COSMIC	AFTSS	DEG_SPOP_SBC_1	0.1389
p.P1257L	SIDM00487	Colorectal Carcinoma	GDSC	AFTSS	DEG_SPOP_SBC_1	0.7582
p.P1257L	CCK-81	large_intestine	COSMIC	AFTSS	DEG_SPOP_SBC_1	0.7582
p.R1264P	ACH-000702	Lymphoma	CCLE	AFTSS	DEG_SPOP_SBC_1	0.2222
p.R1264P	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	AFTSS	DEG_SPOP_SBC_1	0.2222
p.R1264L	ChaGo-K-1	lung	COSMIC	AFTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	1021:1025	AFTSS	SPOP	0.6303	More...
Q9HCK4	Roundabout homolog 2	DEG_SPOP_SBC_1	1256:1260	AFTSS	SPOP	0.9233	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AFTSS

Degron related mutations and impact score

Drug responses associated with ROBO2 mutations

All proteins holding degron of AFTSS