DegronMD

Uniprot ID: Q9HCK4

Source protein: Roundabout homolog 2

Source gene: ROBO2

Class: DEG_SCF_FBW7_1

Location: 1237:1244

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 68.7125

COIL: 0.8351

CONS_SCORE: 0.4246

DSS_SCORE: 0.65

HELIX: 0.1041

FCONS_SCORE: 1.2704

RIG_SCORE: 0.6126

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1254E	TCGA-33-4532	LUSC	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.0556
p.E1229Q	TCGA-49-AARE	LUAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.1111
p.D1238N	TCGA-A5-A0G2	UCEC	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.5821
p.D1254G	TCGA-A5-A0G2	UCEC	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.0556
p.T1230M	TCGA-AA-A00N	COAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.1389
p.D1239N	TCGA-AA-A00N	COAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.6932
p.D1239N	TCGA-LH-A9QB	SKCM	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.6932
p.E1245A	TCGA-AA-A02Y	COAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.3056
p.D1254V	TCGA-B9-A69E	KIRP	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.0556
p.L1228F	TCGA-CA-6717	COAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.0833
p.E1229K	TCGA-EE-A2M6	SKCM	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.1111
p.E1229K	TCGA-GN-A26C	SKCM	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.1111
p.L1250M	TCGA-ER-A2NH	SKCM	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.1667
p.D1231N	TCGA-FR-A7U9	SKCM	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.1667
p.E1240K	TCGA-VQ-A8P2	STAD	TCGA	LDQTPGSS	DEG_SCF_FBW7_1	0.7022
p.E1229A	DO7858	COAD	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	0.1111
p.D1238G	DO222798	COCA	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	0.6087
p.D1238G	DO41235	UCEC	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	0.6087
p.D1238V	DO44513	KIRP	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	0.6674
p.A1236S	DO229028	LICA	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	0.3056
p.D1238E	DO26626	LUSC	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	0.5647
p.P1241S	DO37406	SKCM	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	0.6752
p.L1234M	DO47683	SKCM	ICGC	LDQTPGSS	DEG_SCF_FBW7_1	0.25
p.D1236Y	SIDM00477	Esophageal Carcinoma	GDSC	LDQTPGSS	DEG_SCF_FBW7_1	0.3056
p.D1236Y	OE33	oesophagus	COSMIC	LDQTPGSS	DEG_SCF_FBW7_1	0.3056
p.P1249L	SIDM00795	Melanoma	GDSC	LDQTPGSS	DEG_SCF_FBW7_1	0.1944
p.P1249L	A375	skin	COSMIC	LDQTPGSS	DEG_SCF_FBW7_1	0.1944
p.D1227Y	SIDM01218	Other Solid Cancers	GDSC	LDQTPGSS	DEG_SCF_FBW7_1	0.0556
p.D1227Y	JEG-3	placenta	COSMIC	LDQTPGSS	DEG_SCF_FBW7_1	0.0556
p.P1233L	ACH-000219	Skin Cancer	CCLE	LDQTPGSS	DEG_SCF_FBW7_1	0.2222
p.P1233L	ACH-002001	Skin Cancer	CCLE	LDQTPGSS	DEG_SCF_FBW7_1	0.2222
p.P1233L	ACH-002002	Skin Cancer	CCLE	LDQTPGSS	DEG_SCF_FBW7_1	0.2222
p.P1233L	ACH-002003	Skin Cancer	CCLE	LDQTPGSS	DEG_SCF_FBW7_1	0.2222
p.P1233L	A375	skin	COSMIC	LDQTPGSS	DEG_SCF_FBW7_1	0.2222
p.P1241L	ACH-000963	Colon/Colorectal Cancer	CCLE	LDQTPGSS	DEG_SCF_FBW7_1	0.7582
p.P1241L	CCK-81	large_intestine	COSMIC	LDQTPGSS	DEG_SCF_FBW7_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LDQTPGSS

Degron related mutations and impact score

Drug responses associated with ROBO2 mutations

All proteins holding degron of LDQTPGSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCK4	Roundabout homolog 2	DEG_SCF_FBW7_1	1237:1244	LDQTPGSS	FBXW7	0.9984	More...