DegronMD

Uniprot ID: O43314

Source protein: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

Source gene: PPIP5K2

Class: DEG_SPOP_SBC_1

Location: 1217:1221

E3 ligase: SPOP

DEGRON score: 0.9788

ASA_SCORE: 88.56

COIL: 0.9134

CONS_SCORE: 0.3076

DSS_SCORE: 0.6836

HELIX: 0.0536

FCONS_SCORE: 0.9966

RIG_SCORE: 0.6226

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1221N	TCGA-ND-A4WC	UCS	TCGA	PNTSS	DEG_SPOP_SBC_1	0.6918
p.K1221N	ACH-002280	Neuroblastoma	CCLE	PNTSS	DEG_SPOP_SBC_1	0.6918
p.K1221N	NB13	autonomic_ganglia	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.6918
p.P1228R	SIDM00754	Non-Small Cell Lung Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.1389
p.P1228R	NCI-H1781	lung	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.1389
p.L1225H	SIDM01033	Bladder Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	0.2222
p.L1225H	KU-19-19	urinary_tract	COSMIC	PNTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43314	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2	DEG_SPOP_SBC_1	1217:1221	PNTSS	SPOP	0.9788	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_SPOP_SBC_1	1455:1459	PNTSS	SPOP	0.981	More...
P06213	Insulin receptor	DEG_SPOP_SBC_1	781:785	PNTSS	SPOP	0.9753	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_SPOP_SBC_1	570:574	PNTSS	SPOP	0.7349	More...
Q9UN79	Transcription factor SOX-13	DEG_SPOP_SBC_1	305:309	PNTSS	SPOP	0.9656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons