DegronMD - Q17RS7(GEN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G888A	TCGA-25-2396	OV	TCGA	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.2778
p.G888A	DO31280	OV	ICGC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.2778
p.D892Y	TCGA-44-5644	LUAD	TCGA	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1667
p.D892Y	DO25153	LUAD	ICGC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1667
p.I577M	TCGA-A5-A0VQ	UCEC	TCGA	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.25
p.I577M	DO42113	UCEC	ICGC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.25
p.S874Y	TCGA-AJ-A5DW	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1111
p.S874Y	TCGA-B5-A0JY	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1111
p.S874Y	DO50075	UCEC	ICGC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1111
p.S874Y	DO43041	UCEC	ICGC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1111
p.S874Y	SIDM01611	Endometrial Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1111
p.S874Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1111
p.S574Y	TCGA-AP-A1E0	UCEC	TCGA	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.712
p.S574Y	DO43154	UCEC	ICGC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.712
p.P894H	TCGA-B5-A1MR	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1111
p.P894H	DO41758	UCEC	ICGC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1111
p.L583I	TCGA-DK-A2I2	BLCA	TCGA	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.0833
p.L583I	DO708	BLCA	ICGC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.0833
p.S877Y	TCGA-VQ-A8P2	STAD	TCGA	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1944
p.S877Y	DO51761	STAD	ICGC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.1944
p.I564F	DO222477	ESCA	ICGC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.1667
p.V579L	DO229032	LICA	ICGC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.1944
p.S893I	DO229045	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation blocking phosphorylation signal	0.5833
p.I564T	DO231176	LUSC	ICGC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.1667
p.G888D	DO220901	MELA	ICGC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.2778
p.N885K	DO229213	THCA	ICGC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.6918
p.N885K	SIDM00472	Ovarian Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.6918
p.N885K	SIDM01567	Hodgkin's Lymphoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.6918
p.N885K	PEO1	ovary	COSMIC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.6918
p.S873R	SIDM01141	Ovarian Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00434	Plasma Cell Myeloma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00303	Ovarian Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01036	Plasma Cell Myeloma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00781	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00157	Neuroblastoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00465	Ovarian Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00581	Glioblastoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00002	Neuroblastoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00533	Pancreatic Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00317	Kidney Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00282	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00287	B-Lymphoblastic Leukemia	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00871	Non-Cancerous	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00489	Oral Cavity Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00024	Non-Cancerous	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01088	Endometrial Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00872	Breast Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00502	B-Lymphoblastic Leukemia	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00567	Other Solid Cancers	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01217	Other Blood Cancers	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00324	Neuroblastoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00566	Oral Cavity Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00986	Head and Neck Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01042	Breast Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00274	Gastric Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00302	Other Solid Cancers	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00279	Gastric Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00359	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01569	Hepatocellular Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00168	Head and Neck Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01412	Oral Cavity Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01511	Gastric Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00169	Head and Neck Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01660	Kidney Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01573	Plasma Cell Myeloma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM00780	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01591	Breast Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01454	Kidney Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.S873R	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation rewiring degron network	0.0833
p.E884D	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.6758
p.E884D	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.6758
p.E884D	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKENN	DEG_APCC_KENBOX_2	882:886	Mutation altering degron motif	0.6758
p.S560N	SIDM01652	Non-Cancerous	GDSC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.0556
p.S560N	SIDM00187	Kidney Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.0556
p.S560N	ACH-002352	Non-Cancerous	CCLE	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.0556
p.N571S	SIDM00202	Ewing's Sarcoma	GDSC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.5958
p.N571S	ACH-002118	Bone Cancer	CCLE	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.5958
p.N571S	EW-3	bone	COSMIC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.5958
p.K561E	SIDM01045	Endometrial Carcinoma	GDSC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation substituting flanking lysine	0.1944
p.K561E	ACH-000978	Endometrial/Uterine Cancer	CCLE	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation substituting flanking lysine	0.1944
p.K561E	EN	endometrium	COSMIC	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation substituting flanking lysine	0.1944
p.S567C	ACH-001411	Bladder Cancer	CCLE	PNTSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GEN1

UniProt ID: Q17RS7

Entrez ID: 348654

Protein name: Flap endonuclease GEN homolog 1 (EC 3.1.-.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GEN1 in