DegronMD

Uniprot ID: Q17RS7

Source protein: Flap endonuclease GEN homolog 1

Source gene: GEN1

Class: DEG_APCC_KENBOX_2

Location: 882:886

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8381

ASA_SCORE: 115.8

COIL: 0.798

CONS_SCORE: 0.3185

DSS_SCORE: 0.3726

HELIX: 0.1546

FCONS_SCORE: 0.924

RIG_SCORE: 0.6458

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G888A	TCGA-25-2396	OV	TCGA	KKENN	DEG_APCC_KENBOX_2	0.2778
p.G888A	DO31280	OV	ICGC	KKENN	DEG_APCC_KENBOX_2	0.2778
p.D892Y	TCGA-44-5644	LUAD	TCGA	KKENN	DEG_APCC_KENBOX_2	0.1667
p.D892Y	DO25153	LUAD	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1667
p.S874Y	TCGA-AJ-A5DW	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.1111
p.S874Y	TCGA-B5-A0JY	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.1111
p.S874Y	DO50075	UCEC	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1111
p.S874Y	DO43041	UCEC	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1111
p.S874Y	SIDM01611	Endometrial Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.1111
p.S874Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	KKENN	DEG_APCC_KENBOX_2	0.1111
p.P894H	TCGA-B5-A1MR	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.1111
p.P894H	DO41758	UCEC	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1111
p.S877Y	TCGA-VQ-A8P2	STAD	TCGA	KKENN	DEG_APCC_KENBOX_2	0.1944
p.S877Y	DO51761	STAD	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1944
p.S893I	DO229045	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.5833
p.G888D	DO220901	MELA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.2778
p.N885K	DO229213	THCA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.6918
p.N885K	SIDM00472	Ovarian Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.6918
p.N885K	SIDM01567	Hodgkin's Lymphoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.6918
p.N885K	PEO1	ovary	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.6918
p.S873R	SIDM01141	Ovarian Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00434	Plasma Cell Myeloma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00303	Ovarian Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01036	Plasma Cell Myeloma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00781	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00157	Neuroblastoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00465	Ovarian Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00581	Glioblastoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00002	Neuroblastoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00533	Pancreatic Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00317	Kidney Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00282	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00287	B-Lymphoblastic Leukemia	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00871	Non-Cancerous	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00606	Squamous Cell Lung Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00489	Oral Cavity Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00024	Non-Cancerous	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01088	Endometrial Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00872	Breast Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00502	B-Lymphoblastic Leukemia	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00567	Other Solid Cancers	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01217	Other Blood Cancers	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00324	Neuroblastoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00566	Oral Cavity Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00986	Head and Neck Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01042	Breast Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00274	Gastric Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00302	Other Solid Cancers	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00279	Gastric Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00359	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01569	Hepatocellular Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00168	Head and Neck Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01412	Oral Cavity Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01511	Gastric Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00169	Head and Neck Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01660	Kidney Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01573	Plasma Cell Myeloma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM00780	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01591	Breast Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01454	Kidney Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S873R	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.E884D	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.6758
p.E884D	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.6758
p.E884D	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13378	Homeobox protein Hox-D8	DEG_APCC_KENBOX_2	253:257	KKENN	APC,CDC20,FZR1	0.5012	More...
P17481	Homeobox protein Hox-B8	DEG_APCC_KENBOX_2	202:206	KKENN	APC,CDC20,FZR1	0.8038	More...
P49454	Centromere protein F	DEG_APCC_KENBOX_2	485:489	KKENN	APC,CDC20,FZR1	0.9739	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_APCC_KENBOX_2	882:886	KKENN	APC,CDC20,FZR1	0.8381	More...
Q5VV43	Dyslexia-associated protein KIAA0319	DEG_APCC_KENBOX_2	712:716	KKENN	APC,CDC20,FZR1	0.9185	More...
Q5VXU9	Protein shortage in chiasmata 1 ortholog	DEG_APCC_KENBOX_2	479:483	KKENN	APC,CDC20,FZR1	0.8057	More...
Q8IYD8	Fanconi anemia group M protein	DEG_APCC_KENBOX_2	867:871	KKENN	APC,CDC20,FZR1	0.9394	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_APCC_KENBOX_2	731:735	KKENN	APC,CDC20,FZR1	0.8256	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KKENN

Degron related mutations and impact score

Drug responses associated with GEN1 mutations

All proteins holding degron of KKENN