DegronMD

Uniprot ID: P13378

Source protein: Homeobox protein Hox-D8

Source gene: HOXD8

Class: DEG_APCC_KENBOX_2

Location: 253:257

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5012

ASA_SCORE: 110.7

COIL: 0.6892

CONS_SCORE: 0.6281

DSS_SCORE: 0.4714

HELIX: 0.2828

FCONS_SCORE: 0.9332

RIG_SCORE: 0.7325

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D259G	TCGA-AA-3510	COAD	TCGA	KKENN	DEG_APCC_KENBOX_2	0.2778
p.F261C	TCGA-AA-A010	COAD	TCGA	KKENN	DEG_APCC_KENBOX_2	0.2222
p.F261C	TCGA-B5-A11N	UCEC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.2222
p.D259E	TCGA-OR-A5KB	ACC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.2778
p.D258G	DO7783	COAD	ICGC	KKENN	DEG_APCC_KENBOX_2	0.3056
p.F260C	DO41458	UCEC	ICGC	KKENN	DEG_APCC_KENBOX_2	0.3611
p.P262L	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.1944
p.P262L	NCI-H1915	lung	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.1944
p.P261L	NCI-H1915	lung	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13378	Homeobox protein Hox-D8	DEG_APCC_KENBOX_2	253:257	KKENN	APC,CDC20,FZR1	0.5012	More...
P17481	Homeobox protein Hox-B8	DEG_APCC_KENBOX_2	202:206	KKENN	APC,CDC20,FZR1	0.8038	More...
P49454	Centromere protein F	DEG_APCC_KENBOX_2	485:489	KKENN	APC,CDC20,FZR1	0.9739	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_APCC_KENBOX_2	882:886	KKENN	APC,CDC20,FZR1	0.8381	More...
Q5VV43	Dyslexia-associated protein KIAA0319	DEG_APCC_KENBOX_2	712:716	KKENN	APC,CDC20,FZR1	0.9185	More...
Q5VXU9	Protein shortage in chiasmata 1 ortholog	DEG_APCC_KENBOX_2	479:483	KKENN	APC,CDC20,FZR1	0.8057	More...
Q8IYD8	Fanconi anemia group M protein	DEG_APCC_KENBOX_2	867:871	KKENN	APC,CDC20,FZR1	0.9394	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_APCC_KENBOX_2	731:735	KKENN	APC,CDC20,FZR1	0.8256	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons