DegronMD

Uniprot ID: Q5VV43

Source protein: Dyslexia-associated protein KIAA0319

Source gene: KIAA0319

Class: DEG_APCC_KENBOX_2

Location: 712:716

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9185

ASA_SCORE: 103.16

COIL: 0.7632

CONS_SCORE: 0.3427

DSS_SCORE: 0.5923

HELIX: 0.024

FCONS_SCORE: 0.8605

RIG_SCORE: 0.7013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R720S	TCGA-DD-AAD1	LIHC	TCGA	KKENN	DEG_APCC_KENBOX_2	0.2222
p.R720S	DO52218	LIHC	ICGC	KKENN	DEG_APCC_KENBOX_2	0.2222
p.P718S	TCGA-EE-A3JA	SKCM	TCGA	KKENN	DEG_APCC_KENBOX_2	0.2778
p.P718S	DO47625	SKCM	ICGC	KKENN	DEG_APCC_KENBOX_2	0.2778
p.E714D	TCGA-EI-6882	READ	TCGA	KKENN	DEG_APCC_KENBOX_2	0.6758
p.E714D	DO36531	READ	ICGC	KKENN	DEG_APCC_KENBOX_2	0.6758
p.A721D	DO228976	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.1944
p.S702R	DO229022	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.0556
p.A710D	DO229031	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.2778
p.S702G	DO229058	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.0556
p.V711M	DO229240	THCA	ICGC	KKENN	DEG_APCC_KENBOX_2	0.3056
p.S703N	SIDM01100	Neuroblastoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.S703N	SIDM00049	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	0.0833
p.R711L	NCI-H1299	lung	COSMIC	KKENN	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13378	Homeobox protein Hox-D8	DEG_APCC_KENBOX_2	253:257	KKENN	APC,CDC20,FZR1	0.5012	More...
P17481	Homeobox protein Hox-B8	DEG_APCC_KENBOX_2	202:206	KKENN	APC,CDC20,FZR1	0.8038	More...
P49454	Centromere protein F	DEG_APCC_KENBOX_2	485:489	KKENN	APC,CDC20,FZR1	0.9739	More...
Q17RS7	Flap endonuclease GEN homolog 1	DEG_APCC_KENBOX_2	882:886	KKENN	APC,CDC20,FZR1	0.8381	More...
Q5VV43	Dyslexia-associated protein KIAA0319	DEG_APCC_KENBOX_2	712:716	KKENN	APC,CDC20,FZR1	0.9185	More...
Q5VXU9	Protein shortage in chiasmata 1 ortholog	DEG_APCC_KENBOX_2	479:483	KKENN	APC,CDC20,FZR1	0.8057	More...
Q8IYD8	Fanconi anemia group M protein	DEG_APCC_KENBOX_2	867:871	KKENN	APC,CDC20,FZR1	0.9394	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_APCC_KENBOX_2	731:735	KKENN	APC,CDC20,FZR1	0.8256	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons