DegronMD - P49454(CENPF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1954L	TCGA-05-4397	LUAD	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.0833
p.S1954L	TCGA-CQ-5334	HNSC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.0833
p.S1954L	DO16053	HNSC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.0833
p.S1954L	DO25320	LUAD	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.0833
p.R1964C	TCGA-4E-A92E	UCEC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.8301
p.R1964C	DO228972	LICA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.8301
p.R1964C	DO223277	UCEC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.8301
p.K485R	TCGA-56-7582	LUSC	TCGA	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation altering degron motif	0.6126
p.K485R	DO26976	LUSC	ICGC	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation altering degron motif	0.6126
p.D1978Y	TCGA-99-8025	LUAD	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1389
p.D1978Y	DO24255	LUAD	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1389
p.R1960I	TCGA-A5-A2K5	UCEC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.25
p.R1960I	TCGA-CA-6717	COAD	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.25
p.R1960I	DO8898	COAD	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.25
p.R1960I	DO8264	COAD	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.25
p.R1960I	DO222762	COCA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.25
p.R1960I	DO41379	UCEC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.25
p.S1971T	TCGA-AP-A0LM	UCEC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.6005
p.S1971T	DO43306	UCEC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.6005
p.T1974N	TCGA-B5-A11E	UCEC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.6944
p.T1974N	DO41644	UCEC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.6944
p.T1974N	SIDM01043	Other Sarcomas	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.6944
p.T1974N	ACH-000913	Endometrial/Uterine Cancer	CCLE	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.6944
p.T1974N	ESS-1	endometrium	COSMIC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.6944
p.K1973N	TCGA-BK-A6W3	UCEC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking ubiquitination signal	0.7222
p.K1973N	DO50076	UCEC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking ubiquitination signal	0.7222
p.R256Q	TCGA-BR-8680	STAD	TCGA	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation altering degron motif	0.6218
p.R256Q	DO47769	STAD	ICGC	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation altering degron motif	0.6218
p.T258I	TCGA-D1-A103	UCEC	TCGA	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.3056
p.T258I	DO42312	UCEC	ICGC	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.3056
p.P254Q	TCGA-HU-A4GN	STAD	TCGA	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation altering degron motif	0.7035
p.P254Q	DO47833	STAD	ICGC	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation altering degron motif	0.7035
p.L259V	TCGA-LN-A49P	ESCA	TCGA	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.2778
p.F246L	TCGA-QB-AA9O	SKCM	TCGA	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.1667
p.F246L	DO51267	SKCM	ICGC	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.1667
p.S495C	TCGA-XF-AAMQ	BLCA	TCGA	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation rewiring degron network	0.1667
p.S495C	DO51934	BLCA	ICGC	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation rewiring degron network	0.1667
p.D1978G	DO230334	COCA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1389
p.D1978G	DO229010	COCA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1389
p.D1978G	DO228941	LICA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1389
p.D1978G	DO228974	LICA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1389
p.D1978G	DO229047	LICA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1389
p.D1978G	DO52365	LUSC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation rewiring degron network	0.1389
p.H494Q	DO230334	COCA	ICGC	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation rewiring degron network	0.1944
p.H494Q	DO229010	COCA	ICGC	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation rewiring degron network	0.1944
p.H494Q	DO229013	COCA	ICGC	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation rewiring degron network	0.1944
p.H494Q	DO229505	LAML	ICGC	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation rewiring degron network	0.1944
p.H494Q	DO228941	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation rewiring degron network	0.1944
p.H494Q	DO52365	LUSC	ICGC	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation rewiring degron network	0.1944
p.T1975M	DO233944	GACA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.6667
p.T1975M	SIDM00694	Other Solid Cancers	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.6667
p.T1975M	SIDM00930	Osteosarcoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.6667
p.T1975M	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.6667
p.T1975M	SIDM01409	Bladder Carcinoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.6667
p.T1975M	SIDM01619	Endometrial Carcinoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation blocking phosphorylation signal	0.6667
p.A499S	DO228985	LICA	ICGC	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation rewiring degron network	0.0556
p.L3032V	SIDM00845	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	3028:3032	Mutation altering degron motif	0.5654
p.L3032V	SIDM01519	Head and Neck Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	3028:3032	Mutation altering degron motif	0.5654
p.A3033V	SIDM00845	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	3028:3032	Mutation rewiring degron network	0.3056
p.N489D	SIDM00537	Colorectal Carcinoma	GDSC	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation altering degron motif	0.5821
p.N489D	ACH-000982	Colon/Colorectal Cancer	CCLE	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation altering degron motif	0.5821
p.N489D	ACH-001345	Colon/Colorectal Cancer	CCLE	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation altering degron motif	0.5821
p.N489D	GP5d	large intestine	COSMIC	KKENN	DEG_APCC_KENBOX_2	485:489	Mutation altering degron motif	0.5821
p.M1970V	SIDM00954	Breast Carcinoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.6097
p.S1971P	SIDM00217	Colorectal Carcinoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.5641
p.S1971P	ACH-000999	Colon/Colorectal Cancer	CCLE	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.5641
p.S1971P	SNU-1040	large intestine	COSMIC	LRGELDTMS	DEG_APCC_DBOX_1	1963:1971	Mutation altering degron motif	0.5641
p.A243V	SIDM01617	Endometrial Carcinoma	GDSC	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.0833
p.A243V	ACH-000994	Endometrial/Uterine Cancer	CCLE	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.0833
p.T258N	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.3056
p.T258N	ACH-000851	Lung Cancer	CCLE	VTPSRS	DEG_SCF_FBW7_1	252:257	Mutation rewiring degron network	0.3056

Kaplan plot for CENPF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CENPF

UniProt ID: P49454

Entrez ID: 1063

Protein name: Centromere protein F (CENP-F) (AH antigen) (Kinetochore protein CENPF) (Mitosin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CENPF in