DegronMD

Uniprot ID: P49454

Source protein: Centromere protein F

Source gene: CENPF

Class: DEG_SCF_FBW7_1

Location: 252:257

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 96.55

COIL: 0.7333

CONS_SCORE: 0.4762

DSS_SCORE: 0.5502

HELIX: 0.2612

FCONS_SCORE: 1.2569

RIG_SCORE: 0.7056

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R256Q	TCGA-BR-8680	STAD	TCGA	VTPSRS	DEG_SCF_FBW7_1	0.6218
p.R256Q	DO47769	STAD	ICGC	VTPSRS	DEG_SCF_FBW7_1	0.6218
p.T258I	TCGA-D1-A103	UCEC	TCGA	VTPSRS	DEG_SCF_FBW7_1	0.3056
p.T258I	DO42312	UCEC	ICGC	VTPSRS	DEG_SCF_FBW7_1	0.3056
p.P254Q	TCGA-HU-A4GN	STAD	TCGA	VTPSRS	DEG_SCF_FBW7_1	0.7035
p.P254Q	DO47833	STAD	ICGC	VTPSRS	DEG_SCF_FBW7_1	0.7035
p.L259V	TCGA-LN-A49P	ESCA	TCGA	VTPSRS	DEG_SCF_FBW7_1	0.2778
p.F246L	TCGA-QB-AA9O	SKCM	TCGA	VTPSRS	DEG_SCF_FBW7_1	0.1667
p.F246L	DO51267	SKCM	ICGC	VTPSRS	DEG_SCF_FBW7_1	0.1667
p.A243V	SIDM01617	Endometrial Carcinoma	GDSC	VTPSRS	DEG_SCF_FBW7_1	0.0833
p.A243V	ACH-000994	Endometrial/Uterine Cancer	CCLE	VTPSRS	DEG_SCF_FBW7_1	0.0833
p.T258N	SIDM01628	Non-Small Cell Lung Carcinoma	GDSC	VTPSRS	DEG_SCF_FBW7_1	0.3056
p.T258N	ACH-000851	Lung Cancer	CCLE	VTPSRS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49454	Centromere protein F	DEG_SCF_FBW7_1	252:257	VTPSRS	FBXW7	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons