DegronMD

Uniprot ID: P49454

Source protein: Centromere protein F

Source gene: CENPF

Class: DEG_APCC_DBOX_1

Location: 1963:1971

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6042

ASA_SCORE: 90.1333

COIL: 0.0377

CONS_SCORE: 0.3421

DSS_SCORE: 0.4919

HELIX: 0.9636

FCONS_SCORE: 1.0421

RIG_SCORE: 0.7313

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1954L	TCGA-05-4397	LUAD	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	0.0833
p.S1954L	TCGA-CQ-5334	HNSC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	0.0833
p.S1954L	DO16053	HNSC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.0833
p.S1954L	DO25320	LUAD	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.0833
p.R1964C	TCGA-4E-A92E	UCEC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	0.8301
p.R1964C	DO228972	LICA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.8301
p.R1964C	DO223277	UCEC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.8301
p.D1978Y	TCGA-99-8025	LUAD	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	0.1389
p.D1978Y	DO24255	LUAD	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.1389
p.R1960I	TCGA-A5-A2K5	UCEC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	0.25
p.R1960I	TCGA-CA-6717	COAD	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	0.25
p.R1960I	DO8898	COAD	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.25
p.R1960I	DO8264	COAD	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.25
p.R1960I	DO222762	COCA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.25
p.R1960I	DO41379	UCEC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.25
p.S1971T	TCGA-AP-A0LM	UCEC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	0.6005
p.S1971T	DO43306	UCEC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.6005
p.T1974N	TCGA-B5-A11E	UCEC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	0.6944
p.T1974N	DO41644	UCEC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.6944
p.T1974N	SIDM01043	Other Sarcomas	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	0.6944
p.T1974N	ACH-000913	Endometrial/Uterine Cancer	CCLE	LRGELDTMS	DEG_APCC_DBOX_1	0.6944
p.T1974N	ESS-1	endometrium	COSMIC	LRGELDTMS	DEG_APCC_DBOX_1	0.6944
p.K1973N	TCGA-BK-A6W3	UCEC	TCGA	LRGELDTMS	DEG_APCC_DBOX_1	0.7222
p.K1973N	DO50076	UCEC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.7222
p.D1978G	DO230334	COCA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.1389
p.D1978G	DO229010	COCA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.1389
p.D1978G	DO228941	LICA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.1389
p.D1978G	DO228974	LICA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.1389
p.D1978G	DO229047	LICA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.1389
p.D1978G	DO52365	LUSC	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.1389
p.T1975M	DO233944	GACA	ICGC	LRGELDTMS	DEG_APCC_DBOX_1	0.6667
p.T1975M	SIDM00694	Other Solid Cancers	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	0.6667
p.T1975M	SIDM00930	Osteosarcoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	0.6667
p.T1975M	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	0.6667
p.T1975M	SIDM01409	Bladder Carcinoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	0.6667
p.T1975M	SIDM01619	Endometrial Carcinoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	0.6667
p.M1970V	SIDM00954	Breast Carcinoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	0.6097
p.S1971P	SIDM00217	Colorectal Carcinoma	GDSC	LRGELDTMS	DEG_APCC_DBOX_1	0.5641
p.S1971P	ACH-000999	Colon/Colorectal Cancer	CCLE	LRGELDTMS	DEG_APCC_DBOX_1	0.5641
p.S1971P	SNU-1040	large_intestine	COSMIC	LRGELDTMS	DEG_APCC_DBOX_1	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRGELDTMS

Degron related mutations and impact score

Drug responses associated with CENPF mutations

All proteins holding degron of LRGELDTMS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49454	Centromere protein F	DEG_APCC_DBOX_1	1963:1971	LRGELDTMS	APC,CDC20,FZR1	0.6042	More...