DegronMD

Uniprot ID: P49454

Source protein: Centromere protein F

Source gene: CENPF

Class: DEG_APCC_KENBOX_2

Location: 3028:3032

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9899

ASA_SCORE: 95.7

COIL: 0.543

CONS_SCORE: 0.4072

DSS_SCORE: 0.5232

HELIX: 0.4408

FCONS_SCORE: 1.177

RIG_SCORE: 0.6679

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L3032V	SIDM00845	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.5654
p.L3032V	SIDM01519	Head and Neck Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.5654
p.A3033V	SIDM00845	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.3056

Showing 1 to 3 of 3 entries

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Drug responses associated with CENPF mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of GKENL

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NE21		DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9697	More...
A6NEW6		DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9477	More...
P49454	Centromere protein F	DEG_APCC_KENBOX_2	3028:3032	GKENL	APC,CDC20,FZR1	0.9899	More...
Q15768	Ephrin-B3	DEG_APCC_KENBOX_2	199:203	GKENL	APC,CDC20,FZR1	0.8597	More...
Q8WXH0	Nesprin-2	DEG_APCC_KENBOX_2	1566:1570	GKENL	APC,CDC20,FZR1	0.7996	More...
Q86YD7	Protein FAM90A1	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9665	More...
A6NDY2	Putative protein FAM90A10	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9783	More...
A8MX19	Putative protein FAM90A12P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9571	More...
P0C7W8	Putative protein FAM90A13P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9618	More...
P0C7W9	Putative protein FAM90A14	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9533	More...
P0C7V4	Putative protein FAM90A15P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9428	More...
A6NIJ5	Putative protein FAM90A20P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9924	More...
A8MWA6	Putative protein FAM90A22	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9637	More...
A8MXZ1	Putative protein FAM90A23	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9521	More...
P0C7X0	Putative protein FAM90A24P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9616	More...
D6RGX4	Putative protein FAM90A26	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9836	More...
Q658T7	Putative protein FAM90A2P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.944	More...
A8MXJ8	Putative protein FAM90A5P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9533	More...
A6NKC0	Putative protein FAM90A7	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9691	More...
A6NJQ4	Putative protein FAM90A8	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9623	More...
A6NNJ1	Putative protein FAM90A9	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9527	More...

Showing 1 to 21 of 21 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GKENL

Degron related mutations and impact score

Drug responses associated with CENPF mutations

All proteins holding degron of GKENL