DegronMD

Uniprot ID: Q15768

Source protein: Ephrin-B3

Source gene: EFNB3

Class: DEG_APCC_KENBOX_2

Location: 199:203

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8597

ASA_SCORE: 79.52

COIL: 0.8538

CONS_SCORE: 0.466

DSS_SCORE: 0.7939

HELIX: 0.0686

FCONS_SCORE: 1.0145

RIG_SCORE: 0.5297

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P207H	TCGA-95-7039	LUAD	TCGA	GKENL	DEG_APCC_KENBOX_2	0.2222
p.P207H	DO23907	LUAD	ICGC	GKENL	DEG_APCC_KENBOX_2	0.2222
p.H194R	DO229234	THCA	ICGC	GKENL	DEG_APCC_KENBOX_2	0.1944
p.T208S	SIDM00845	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.1944
p.T208S	SIDM00461	Acute Myeloid Leukemia	GDSC	GKENL	DEG_APCC_KENBOX_2	0.1944
p.T208S	SIDM01519	Head and Neck Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.1944
p.T208S	ACH-000786	Lymphoma	CCLE	GKENL	DEG_APCC_KENBOX_2	0.1944
p.T208S	ACH-000992	Head and Neck Cancer	CCLE	GKENL	DEG_APCC_KENBOX_2	0.1944
p.T208S	ACH-001067	Brain Cancer	CCLE	GKENL	DEG_APCC_KENBOX_2	0.1944
p.T208S	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	GKENL	DEG_APCC_KENBOX_2	0.1944
p.T208S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	GKENL	DEG_APCC_KENBOX_2	0.1944
p.A193D	TCGA-DM-A1D8	COAD	TCGA	GKENL	DEG_APCC_KENBOX_2	0.1667
p.A193D	DO8914	COAD	ICGC	GKENL	DEG_APCC_KENBOX_2	0.1667
p.N210S	TCGA-GN-A8LK	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	0.1389
p.N210S	DO51259	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	0.1389
p.A192T	DO223505	CLLE	ICGC	GKENL	DEG_APCC_KENBOX_2	0.1389
p.S213F	SIDM00685	Glioblastoma	GDSC	GKENL	DEG_APCC_KENBOX_2	0.0556
p.S213F	ACH-000819	Brain Cancer	CCLE	GKENL	DEG_APCC_KENBOX_2	0.0556
p.S213F	LN-18	central_nervous_system	COSMIC	GKENL	DEG_APCC_KENBOX_2	0.0556
p.SR213SW	DO222824	MELA	ICGC	GKENL	DEG_APCC_KENBOX_2	0

Showing 1 to 20 of 20 entries

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Drug responses associated with EFNB3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of GKENL

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NE21		DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9697	More...
A6NEW6		DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9477	More...
P49454	Centromere protein F	DEG_APCC_KENBOX_2	3028:3032	GKENL	APC,CDC20,FZR1	0.9899	More...
Q15768	Ephrin-B3	DEG_APCC_KENBOX_2	199:203	GKENL	APC,CDC20,FZR1	0.8597	More...
Q8WXH0	Nesprin-2	DEG_APCC_KENBOX_2	1566:1570	GKENL	APC,CDC20,FZR1	0.7996	More...
Q86YD7	Protein FAM90A1	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9665	More...
A6NDY2	Putative protein FAM90A10	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9783	More...
A8MX19	Putative protein FAM90A12P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9571	More...
P0C7W8	Putative protein FAM90A13P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9618	More...
P0C7W9	Putative protein FAM90A14	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9533	More...
P0C7V4	Putative protein FAM90A15P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9428	More...
A6NIJ5	Putative protein FAM90A20P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9924	More...
A8MWA6	Putative protein FAM90A22	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9637	More...
A8MXZ1	Putative protein FAM90A23	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9521	More...
P0C7X0	Putative protein FAM90A24P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9616	More...
D6RGX4	Putative protein FAM90A26	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9836	More...
Q658T7	Putative protein FAM90A2P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.944	More...
A8MXJ8	Putative protein FAM90A5P	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9533	More...
A6NKC0	Putative protein FAM90A7	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9691	More...
A6NJQ4	Putative protein FAM90A8	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9623	More...
A6NNJ1	Putative protein FAM90A9	DEG_APCC_KENBOX_2	78:82	GKENL	APC,CDC20,FZR1	0.9527	More...

Showing 1 to 21 of 21 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GKENL

Degron related mutations and impact score

Drug responses associated with EFNB3 mutations

All proteins holding degron of GKENL