DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
GKENL
Uniprot ID:
A8MXJ8
Source protein:
Putative protein FAM90A5P
Source gene:
FAM90A5P
Class:
DEG_APCC_KENBOX_2
Location:
78:82
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9533
ASA_SCORE:
94.2
COIL:
0.833
CONS_SCORE:
0.7487
DSS_SCORE:
0.5521
HELIX:
0.07
FCONS_SCORE:
1.6185
RIG_SCORE:
0.6808
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM90A5P mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of GKENL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P49454
Centromere protein F
DEG_APCC_KENBOX_2
3028:3032
GKENL
APC,CDC20,FZR1
0.9899
More...
Q15768
Ephrin-B3
DEG_APCC_KENBOX_2
199:203
GKENL
APC,CDC20,FZR1
0.8597
More...
Q86YD7
Protein FAM90A1
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9665
More...
Q8WXH0
Nesprin-2
DEG_APCC_KENBOX_2
1566:1570
GKENL
APC,CDC20,FZR1
0.7996
More...
A6NDY2
Putative protein FAM90A10
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9783
More...
A6NE21
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9697
More...
A6NEW6
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9477
More...
A6NIJ5
Putative protein FAM90A20P
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9924
More...
A6NJQ4
Putative protein FAM90A8
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9623
More...
A6NKC0
Putative protein FAM90A7
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9691
More...
A6NNJ1
Putative protein FAM90A9
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9527
More...
A8MWA6
Putative protein FAM90A22
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9637
More...
A8MX19
Putative protein FAM90A12P
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9571
More...
A8MXJ8
Putative protein FAM90A5P
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9533
More...
A8MXZ1
Putative protein FAM90A23
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9521
More...
D6RGX4
Putative protein FAM90A26
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9836
More...
P0C7V4
Putative protein FAM90A15P
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9428
More...
P0C7W8
Putative protein FAM90A13P
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9618
More...
P0C7W9
Putative protein FAM90A14
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9533
More...
P0C7X0
Putative protein FAM90A24P
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.9616
More...
Q658T7
Putative protein FAM90A2P
DEG_APCC_KENBOX_2
78:82
GKENL
APC,CDC20,FZR1
0.944
More...