DegronMD - Q8WXH0(SYNE2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R2155K	TCGA-18-5595	LUSC	TCGA	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation altering degron motif	0.7237
p.R2155K	DO27373	LUSC	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation altering degron motif	0.7237
p.R2155S	TCGA-18-5595	LUSC	TCGA	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation altering degron motif	0.7427
p.R2155S	DO27373	LUSC	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation altering degron motif	0.7427
p.S1559Y	TCGA-66-2727	LUSC	TCGA	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.1389
p.S1559Y	DO26478	LUSC	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.1389
p.V1580A	TCGA-AX-A1CE	UCEC	TCGA	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.0556
p.V1580A	DO42280	UCEC	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.0556
p.K2146R	TCGA-AX-A1CE	UCEC	TCGA	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation substituting flanking lysine	0.2222
p.K2146R	DO42280	UCEC	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation substituting flanking lysine	0.2222
p.S4158F	TCGA-B0-5094	KIRC	TCGA	ASSSS	DEG_SPOP_SBC_1	4155:4159	Mutation altering degron motif	0.9093
p.L4071F	TCGA-CN-6011	HNSC	TCGA	ERDRLPAVT	DEG_APCC_DBOX_1	4079:4087	Mutation rewiring degron network	0.1111
p.Q4069K	TCGA-D3-A2JP	SKCM	TCGA	ERDRLPAVT	DEG_APCC_DBOX_1	4079:4087	Mutation rewiring degron network	0.0556
p.D6473N	TCGA-DI-A1BU	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.1111
p.E4095Q	TCGA-DR-A0ZM	CESC	TCGA	ERDRLPAVT	DEG_APCC_DBOX_1	4079:4087	Mutation rewiring degron network	0.1111
p.S1563L	TCGA-EE-A2M5	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.25
p.S1563L	DO222423	MELA	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.25
p.S1563L	DO37425	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.25
p.S1563L	ACH-001412	Bladder Cancer	CCLE	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.25
p.E6487K	TCGA-EO-A3B0	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation blocking phosphorylation signal	0.7222
p.Y4167C	TCGA-EO-A3KX	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	4155:4159	Mutation blocking phosphorylation signal	0.5556
p.M6493I	TCGA-FI-A2D0	UCEC	TCGA	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation substituting flanking lysine	0.2222
p.M1565I	TCGA-FS-A1ZB	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.3056
p.M1565I	DO37886	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.3056
p.L2158F	TCGA-G4-6309	COAD	TCGA	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation altering degron motif	0.6981
p.L2158F	DO7810	COAD	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation altering degron motif	0.6981
p.G4160R	TCGA-HU-8244	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	4155:4159	Mutation rewiring degron network	0.3056
p.D6481N	TCGA-W3-A824	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation altering degron motif	0.6932
p.T1558A	DO230323	COCA	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.1111
p.L1571M	DO229010	COCA	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.3056
p.L1571M	DO229013	COCA	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.3056
p.L1571M	DO229016	COCA	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.3056
p.L1571M	DO229003	COCA	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.3056
p.I1579V	DO228761	GACA	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.0833
p.G2168C	DO229019	LICA	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation rewiring degron network	0.1667
p.E4154G	DO229059	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	4155:4159	Mutation rewiring degron network	0.3056
p.I2159M	DO229257	THCA	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation altering degron motif	0.6507
p.L1578M	DO42472	UCEC	ICGC	GKENL	DEG_APCC_KENBOX_2	1566:1570	Mutation rewiring degron network	0.1111
p.S4156C	SIDM00353	Other Sarcomas	GDSC	ASSSS	DEG_SPOP_SBC_1	4155:4159	Mutation altering degron motif	0.7541
p.S4156C	RKN	ovary	COSMIC	ASSSS	DEG_SPOP_SBC_1	4155:4159	Mutation altering degron motif	0.7541
p.S6472L	SIDM00848	Ewing's Sarcoma	GDSC	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.0833
p.S6472L	SIDM01106	Melanoma	GDSC	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.0833
p.S6472L	SIDM01247	Burkitt's Lymphoma	GDSC	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.0833
p.S6472L	SIDM00794	Other Solid Cancers	GDSC	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.0833
p.S6472L	SIDM00176	Chondrosarcoma	GDSC	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.0833
p.S6472L	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.0833
p.Q4073R	SIDM00789	Colorectal Carcinoma	GDSC	ERDRLPAVT	DEG_APCC_DBOX_1	4079:4087	Mutation rewiring degron network	0.1667
p.Q4073R	HCT-15	large intestine	COSMIC	ERDRLPAVT	DEG_APCC_DBOX_1	4079:4087	Mutation rewiring degron network	0.1667
p.L2171V	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation rewiring degron network	0.0833
p.G4077V	SIDM00530	Esophageal Carcinoma	GDSC	ERDRLPAVT	DEG_APCC_DBOX_1	4079:4087	Mutation rewiring degron network	0.2778
p.G4077V	SIDM00821	Kidney Carcinoma	GDSC	ERDRLPAVT	DEG_APCC_DBOX_1	4079:4087	Mutation rewiring degron network	0.2778
p.G4077V	KYAE-1	oesophagus	COSMIC	ERDRLPAVT	DEG_APCC_DBOX_1	4079:4087	Mutation rewiring degron network	0.2778
p.M2157T	SIDM00785	Acute Myeloid Leukemia	GDSC	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation altering degron motif	0.6312
p.M2157T	KG-1	haematopoietic and lymphoid tissue	COSMIC	LRLMLIELK	DEG_APCC_DBOX_1	2154:2162	Mutation altering degron motif	0.6312
p.E4151G	ACH-000961	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	4155:4159	Mutation rewiring degron network	0.2222
p.A6478T	ACH-001113	Lung Cancer	CCLE	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.25
p.A6478T	ACH-002156	Lung Cancer	CCLE	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.25
p.A6478T	LC-1-sq	lung	COSMIC	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.25
p.S4156F	ACH-001362	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	4155:4159	Mutation altering degron motif	0.7982
p.S4156F	NCI-H1770	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	4155:4159	Mutation altering degron motif	0.7982
p.S6484G	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation altering degron motif	0.8104
p.Q6476P	H513	pleura	COSMIC	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.1944
p.A6484T	LC-1-sq	lung	COSMIC	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation altering degron motif	0.7139
p.P6478S	UACC-812	breast	COSMIC	PASST	DEG_SPOP_SBC_1	6481:6485	Mutation rewiring degron network	0.25

Kaplan plot for SYNE2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYNE2

UniProt ID: Q8WXH0

Entrez ID: 23224

Protein name: Nesprin-2 (KASH domain-containing protein 2) (KASH2) (Nuclear envelope spectrin repeat protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE) (Synaptic nuclear envelope protein 2) (Syne-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYNE2 in