DegronMD

Uniprot ID: Q8WXH0

Source protein: Nesprin-2

Source gene: SYNE2

Class: DEG_APCC_DBOX_1

Location: 2154:2162

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5613

ASA_SCORE: 70.2

COIL: 0.0066

CONS_SCORE: 0.484

DSS_SCORE: 0.1399

HELIX: 0.9932

FCONS_SCORE: 1.2724

RIG_SCORE: 0.8872

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2155K	TCGA-18-5595	LUSC	TCGA	LRLMLIELK	DEG_APCC_DBOX_1	0.7237
p.R2155K	DO27373	LUSC	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	0.7237
p.R2155S	TCGA-18-5595	LUSC	TCGA	LRLMLIELK	DEG_APCC_DBOX_1	0.7427
p.R2155S	DO27373	LUSC	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	0.7427
p.K2146R	TCGA-AX-A1CE	UCEC	TCGA	LRLMLIELK	DEG_APCC_DBOX_1	0.2222
p.K2146R	DO42280	UCEC	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	0.2222
p.L2158F	TCGA-G4-6309	COAD	TCGA	LRLMLIELK	DEG_APCC_DBOX_1	0.6981
p.L2158F	DO7810	COAD	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	0.6981
p.G2168C	DO229019	LICA	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	0.1667
p.I2159M	DO229257	THCA	ICGC	LRLMLIELK	DEG_APCC_DBOX_1	0.6507
p.L2171V	SIDM00810	Non-Small Cell Lung Carcinoma	GDSC	LRLMLIELK	DEG_APCC_DBOX_1	0.0833
p.M2157T	SIDM00785	Acute Myeloid Leukemia	GDSC	LRLMLIELK	DEG_APCC_DBOX_1	0.6312
p.M2157T	KG-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRLMLIELK	DEG_APCC_DBOX_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXH0	Nesprin-2	DEG_APCC_DBOX_1	2154:2162	LRLMLIELK	APC,CDC20,FZR1	0.5613	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons