DegronMD

Uniprot ID: Q8WXH0

Source protein: Nesprin-2

Source gene: SYNE2

Class: DEG_APCC_DBOX_1

Location: 4079:4087

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6464

ASA_SCORE: 105.0333

COIL: 0.6584

CONS_SCORE: 0.3658

DSS_SCORE: 0.5941

HELIX: 0.311

FCONS_SCORE: 0.9209

RIG_SCORE: 0.7141

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L4071F	TCGA-CN-6011	HNSC	TCGA	ERDRLPAVT	DEG_APCC_DBOX_1	0.1111
p.Q4069K	TCGA-D3-A2JP	SKCM	TCGA	ERDRLPAVT	DEG_APCC_DBOX_1	0.0556
p.E4095Q	TCGA-DR-A0ZM	CESC	TCGA	ERDRLPAVT	DEG_APCC_DBOX_1	0.1111
p.Q4073R	SIDM00789	Colorectal Carcinoma	GDSC	ERDRLPAVT	DEG_APCC_DBOX_1	0.1667
p.Q4073R	HCT-15	large_intestine	COSMIC	ERDRLPAVT	DEG_APCC_DBOX_1	0.1667
p.G4077V	SIDM00530	Esophageal Carcinoma	GDSC	ERDRLPAVT	DEG_APCC_DBOX_1	0.2778
p.G4077V	SIDM00821	Kidney Carcinoma	GDSC	ERDRLPAVT	DEG_APCC_DBOX_1	0.2778
p.G4077V	KYAE-1	oesophagus	COSMIC	ERDRLPAVT	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXH0	Nesprin-2	DEG_APCC_DBOX_1	4079:4087	ERDRLPAVT	APC,CDC20,FZR1	0.6464	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons