DegronMD - Q86YD7(FAM90A1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P453S	TCGA-19-5956	GBM	TCGA	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.5641
p.P453S	DO13863	GBM	ICGC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.5641
p.P453S	SIDM00095	Glioblastoma	GDSC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.5641
p.P453S	SNB75	central nervous system	COSMIC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.5641
p.D460N	TCGA-2W-A8YY	CESC	TCGA	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.D460N	TCGA-A5-A1OF	UCEC	TCGA	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.D460N	TCGA-FR-A8YC	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.D460N	DO223732	CESC	ICGC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.D460N	DO50301	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.D460N	DO42568	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.K79E	TCGA-2W-A8YY	CESC	TCGA	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation altering degron motif	0.7022
p.K79E	DO223732	CESC	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation altering degron motif	0.7022
p.P87L	TCGA-A5-A0G2	UCEC	TCGA	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.1944
p.P87L	DO41235	UCEC	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.1944
p.N72K	TCGA-BA-4074	HNSC	TCGA	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.1667
p.N72K	DO14710	HNSC	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.1667
p.R144M	TCGA-BS-A0UF	UCEC	TCGA	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1111
p.R144M	DO41488	UCEC	ICGC	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1111
p.G78E	TCGA-D3-A2JO	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation altering degron motif	0.6087
p.G78E	TCGA-GN-A263	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation altering degron motif	0.6087
p.G78E	DO37766	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation altering degron motif	0.6087
p.G78E	DO47619	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation altering degron motif	0.6087
p.E77K	TCGA-D3-A8GL	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.3056
p.E77K	TCGA-EE-A182	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.3056
p.E77K	TCGA-EE-A29R	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.3056
p.E77K	DO37814	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.3056
p.E77K	DO37448	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.3056
p.E77K	DO50287	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.3056
p.P87S	TCGA-D7-6524	STAD	TCGA	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.1944
p.P87S	DO38368	STAD	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.1944
p.E75K	TCGA-EB-A5UM	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.25
p.E75K	TCGA-FW-A3R5	SKCM	TCGA	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.25
p.E75K	DO47282	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.25
p.E75K	DO37406	SKCM	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.25
p.M150I	TCGA-FI-A2D5	UCEC	TCGA	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.2778
p.M150I	DO41331	UCEC	ICGC	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.2778
p.S455F	TCGA-FS-A4FC	SKCM	TCGA	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7982
p.S455F	DO37762	SKCM	ICGC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7982
p.P159S	TCGA-HF-A5NB	STAD	TCGA	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.25
p.P159S	DO50127	STAD	ICGC	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.25
p.V445I	TCGA-UF-A7JF	HNSC	TCGA	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1389
p.V445I	DO52116	HNSC	ICGC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1389
p.R160S	TCGA-VQ-A8PO	STAD	TCGA	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.2222
p.R160S	DO51773	STAD	ICGC	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.2222
p.P71Q	DO229015	LICA	ICGC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.1389
p.V161L	DO229030	LICA	ICGC	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1944
p.D460V	DO23482	LINC	ICGC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2222
p.P151L	DO45299	LIRI	ICGC	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.3056
p.L165P	DO36556	READ	ICGC	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.0833
p.Q451H	DO42304	UCEC	ICGC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.3056
p.A91G	SIDM00845	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM00969	Ovarian Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM01126	Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM00200	Ewing's Sarcoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM00654	Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM00694	Other Solid Cancers	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM01101	Neuroblastoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM00849	Kidney Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM00254	Neuroblastoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM00032	Bladder Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM00907	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM00673	Breast Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.A91G	SIDM00760	Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.0833
p.K76N	SIDM00845	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.2778
p.K76N	SIDM00200	Ewing's Sarcoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.2778
p.K76N	SIDM00654	Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.2778
p.K76N	SIDM00694	Other Solid Cancers	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.2778
p.K76N	SIDM01101	Neuroblastoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.2778
p.K76N	SIDM00907	Burkitt's Lymphoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.2778
p.K76N	SIDM00673	Breast Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.2778
p.K76N	SIDM00760	Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.2778
p.S455C	SIDM00206	Glioblastoma	GDSC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7541
p.S455C	ACH-002231	Brain Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7541
p.S455C	D-566MG	central nervous system	COSMIC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.7541
p.P453L	SIDM00327	Hodgkin's Lymphoma	GDSC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.6471
p.P453L	ACH-000754	Lymphoma	CCLE	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.6471
p.P453L	L-428	haematopoietic and lymphoid tissue	COSMIC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation altering degron motif	0.6471
p.S156I	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.7341
p.S156I	ACH-000917	Esophageal Cancer	CCLE	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.7341
p.S156I	TE-4	oesophagus	COSMIC	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.7341
p.L450V	SIDM00760	Small Cell Lung Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2778
p.L450V	ACH-000729	Lung Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2778
p.L450V	NCI-H1963	lung	COSMIC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.2778
p.V445F	SIDM00638	Cervical Carcinoma	GDSC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1389
p.V445F	ACH-001360	Cervical Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1389
p.V445F	MS751	cervix	COSMIC	VPSSS	DEG_SPOP_SBC_1	452:456	Mutation rewiring degron network	0.1389
p.Q88R	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	GKENL	DEG_APCC_KENBOX_2	78:82	Mutation rewiring degron network	0.1667
p.S156G	SIDM01445	Gastric Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.6993
p.S156G	SIDM00171	Colorectal Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation altering degron motif	0.6993
p.P163L	ACH-000988	Endometrial/Uterine Cancer	CCLE	VHTTS	DEG_SPOP_SBC_1	152:156	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM90A1

UniProt ID: Q86YD7

Entrez ID: 55138

Protein name: Protein FAM90A1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM90A1 in