DegronMD

Uniprot ID: Q86YD7

Source protein: Protein FAM90A1

Source gene: FAM90A1

Class: DEG_SPOP_SBC_1

Location: 152:156

E3 ligase: SPOP

DEGRON score: 0.6922

ASA_SCORE: 82.74

COIL: 0.8514

CONS_SCORE: 0.4134

DSS_SCORE: 0.6291

HELIX: 0.034

FCONS_SCORE: 0.6901

RIG_SCORE: 0.6666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R144M	TCGA-BS-A0UF	UCEC	TCGA	VHTTS	DEG_SPOP_SBC_1	0.1111
p.R144M	DO41488	UCEC	ICGC	VHTTS	DEG_SPOP_SBC_1	0.1111
p.M150I	TCGA-FI-A2D5	UCEC	TCGA	VHTTS	DEG_SPOP_SBC_1	0.2778
p.M150I	DO41331	UCEC	ICGC	VHTTS	DEG_SPOP_SBC_1	0.2778
p.P159S	TCGA-HF-A5NB	STAD	TCGA	VHTTS	DEG_SPOP_SBC_1	0.25
p.P159S	DO50127	STAD	ICGC	VHTTS	DEG_SPOP_SBC_1	0.25
p.R160S	TCGA-VQ-A8PO	STAD	TCGA	VHTTS	DEG_SPOP_SBC_1	0.2222
p.R160S	DO51773	STAD	ICGC	VHTTS	DEG_SPOP_SBC_1	0.2222
p.V161L	DO229030	LICA	ICGC	VHTTS	DEG_SPOP_SBC_1	0.1944
p.P151L	DO45299	LIRI	ICGC	VHTTS	DEG_SPOP_SBC_1	0.3056
p.L165P	DO36556	READ	ICGC	VHTTS	DEG_SPOP_SBC_1	0.0833
p.S156I	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	0.7341
p.S156I	ACH-000917	Esophageal Cancer	CCLE	VHTTS	DEG_SPOP_SBC_1	0.7341
p.S156I	TE-4	oesophagus	COSMIC	VHTTS	DEG_SPOP_SBC_1	0.7341
p.S156G	SIDM01445	Gastric Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	0.6993
p.S156G	SIDM00171	Colorectal Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	0.6993
p.P163L	ACH-000988	Endometrial/Uterine Cancer	CCLE	VHTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YD7	Protein FAM90A1	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.6922	More...
Q8IWE5	Pleckstrin homology domain-containing family M member 2	DEG_SPOP_SBC_1	288:292	VHTTS	SPOP	0.8723	More...
Q92618	Zinc finger protein 516	DEG_SPOP_SBC_1	1134:1138	VHTTS	SPOP	0.9673	More...
A6NDY2	Putative protein FAM90A10	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.6026	More...
A6NE21		DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.7681	More...
A6NKC0	Putative protein FAM90A7	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.7459	More...
A8MWA6	Putative protein FAM90A22	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9225	More...
A8MXZ1	Putative protein FAM90A23	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.5879	More...
D6RGX4	Putative protein FAM90A26	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.976	More...
P0C7V4	Putative protein FAM90A15P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.72	More...
P0C7W8	Putative protein FAM90A13P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9301	More...
P0C7W9	Putative protein FAM90A14	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9792	More...
P0C7X0	Putative protein FAM90A24P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9832	More...
Q658T7	Putative protein FAM90A2P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons