DegronMD - Q92618(ZNF516)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1141T	TCGA-AM-5821	COAD	TCGA	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.25
p.A1141T	DO8240	COAD	ICGC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.25
p.A1141T	DO234183	ESAD	ICGC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.25
p.A1141T	SIDM01314	Colorectal Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.25
p.A1141T	SIDM00282	Colorectal Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.25
p.A1141T	ACH-000998	Colon/Colorectal Cancer	CCLE	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.25
p.A1141T	CW-2	large intestine	COSMIC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.25
p.G1145W	TCGA-EE-A2GN	SKCM	TCGA	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.1389
p.G1145W	TCGA-FS-A1ZB	SKCM	TCGA	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.1389
p.G1145W	TCGA-G9-6342	PRAD	TCGA	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.1389
p.D1140E	DO229029	LICA	ICGC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.2778
p.T1136N	DO229031	LICA	ICGC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation altering degron motif	0.7055
p.R1146K	DO23786	LUAD	ICGC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.1111
p.R1130Q	DO230560	PRAD	ICGC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.2222
p.D1147E	SIDM01039	Other Solid Cancers	GDSC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.0833
p.D1147E	ACH-001529	Endometrial/Uterine Cancer	CCLE	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.0833
p.D1147E	JAR	placenta	COSMIC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.0833
p.S1126A	SIDM01173	Rhabdomyosarcoma	GDSC	VHTTS	DEG_SPOP_SBC_1	1134:1138	Mutation rewiring degron network	0.1111

Kaplan plot for ZNF516 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF516

UniProt ID: Q92618

Entrez ID: 9658

Protein name: Zinc finger protein 516

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF516 in