DegronMD

Uniprot ID: Q92618

Source protein: Zinc finger protein 516

Source gene: ZNF516

Class: DEG_SPOP_SBC_1

Location: 1134:1138

E3 ligase: SPOP

DEGRON score: 0.9673

ASA_SCORE: 51.52

COIL: 0.6848

CONS_SCORE: 0.4947

DSS_SCORE: 0.7669

HELIX: 0.1096

FCONS_SCORE: 1.169

RIG_SCORE: 0.6569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1141T	TCGA-AM-5821	COAD	TCGA	VHTTS	DEG_SPOP_SBC_1	0.25
p.A1141T	DO8240	COAD	ICGC	VHTTS	DEG_SPOP_SBC_1	0.25
p.A1141T	DO234183	ESAD	ICGC	VHTTS	DEG_SPOP_SBC_1	0.25
p.A1141T	SIDM01314	Colorectal Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	0.25
p.A1141T	SIDM00282	Colorectal Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	0.25
p.A1141T	ACH-000998	Colon/Colorectal Cancer	CCLE	VHTTS	DEG_SPOP_SBC_1	0.25
p.A1141T	CW-2	large_intestine	COSMIC	VHTTS	DEG_SPOP_SBC_1	0.25
p.G1145W	TCGA-EE-A2GN	SKCM	TCGA	VHTTS	DEG_SPOP_SBC_1	0.1389
p.G1145W	TCGA-FS-A1ZB	SKCM	TCGA	VHTTS	DEG_SPOP_SBC_1	0.1389
p.G1145W	TCGA-G9-6342	PRAD	TCGA	VHTTS	DEG_SPOP_SBC_1	0.1389
p.D1140E	DO229029	LICA	ICGC	VHTTS	DEG_SPOP_SBC_1	0.2778
p.T1136N	DO229031	LICA	ICGC	VHTTS	DEG_SPOP_SBC_1	0.7055
p.R1146K	DO23786	LUAD	ICGC	VHTTS	DEG_SPOP_SBC_1	0.1111
p.R1130Q	DO230560	PRAD	ICGC	VHTTS	DEG_SPOP_SBC_1	0.2222
p.D1147E	SIDM01039	Other Solid Cancers	GDSC	VHTTS	DEG_SPOP_SBC_1	0.0833
p.D1147E	ACH-001529	Endometrial/Uterine Cancer	CCLE	VHTTS	DEG_SPOP_SBC_1	0.0833
p.D1147E	JAR	placenta	COSMIC	VHTTS	DEG_SPOP_SBC_1	0.0833
p.S1126A	SIDM01173	Rhabdomyosarcoma	GDSC	VHTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YD7	Protein FAM90A1	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.6922	More...
Q8IWE5	Pleckstrin homology domain-containing family M member 2	DEG_SPOP_SBC_1	288:292	VHTTS	SPOP	0.8723	More...
Q92618	Zinc finger protein 516	DEG_SPOP_SBC_1	1134:1138	VHTTS	SPOP	0.9673	More...
A6NDY2	Putative protein FAM90A10	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.6026	More...
A6NE21		DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.7681	More...
A6NKC0	Putative protein FAM90A7	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.7459	More...
A8MWA6	Putative protein FAM90A22	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9225	More...
A8MXZ1	Putative protein FAM90A23	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.5879	More...
D6RGX4	Putative protein FAM90A26	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.976	More...
P0C7V4	Putative protein FAM90A15P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.72	More...
P0C7W8	Putative protein FAM90A13P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9301	More...
P0C7W9	Putative protein FAM90A14	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9792	More...
P0C7X0	Putative protein FAM90A24P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9832	More...
Q658T7	Putative protein FAM90A2P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons