DegronMD - Q8IWE5(PLEKHM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V288M	TCGA-2W-A8YY	CESC	TCGA	VHTTS	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7208
p.S389F	TCGA-BR-A4QL	STAD	TCGA	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.1667
p.P379L	TCGA-FI-A2D4	UCEC	TCGA	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation altering degron motif	0.7582
p.T279I	TCGA-G4-6302	COAD	TCGA	VHTTS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.0833
p.L373R	DO233258	GACA	ICGC	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.1667
p.P389S	DO233779	GACA	ICGC	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.1667
p.K379N	DO228952	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation altering degron motif	0.6918
p.D285Y	DO229035	LICA	ICGC	VHTTS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.25
p.T288M	DO38723	STAD	ICGC	VHTTS	DEG_SPOP_SBC_1	288:292	Mutation altering degron motif	0.7423
p.S369F	DO38723	STAD	ICGC	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.0556
p.A298T	SIDM01293	Colorectal Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	288:292	Mutation rewiring degron network	0.1667
p.R388C	SIDM00980	Gastric Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.1944
p.R388C	ACH-000948	Gastric Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.1944
p.R388C	23132-87	stomach	COSMIC	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.1944
p.L369P	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.0556
p.L369P	ACH-000942	Leukemia	CCLE	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.0556
p.G378R	huH-1	liver	COSMIC	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.3056
p.G378R	TE-11	oesophagus	COSMIC	PSSTT	DEG_SPOP_SBC_1	379:383	Mutation rewiring degron network	0.3056

Kaplan plot for PLEKHM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHM2

UniProt ID: Q8IWE5

Entrez ID: 23207

Protein name: Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHM2 in