DegronMD

Uniprot ID: Q8IWE5

Source protein: Pleckstrin homology domain-containing family M member 2

Source gene: PLEKHM2

Class: DEG_SPOP_SBC_1

Location: 288:292

E3 ligase: SPOP

DEGRON score: 0.8723

ASA_SCORE: 88.48

COIL: 0.8446

CONS_SCORE: 0.3685

DSS_SCORE: 0.7256

HELIX: 0.123

FCONS_SCORE: 1.0783

RIG_SCORE: 0.651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V288M	TCGA-2W-A8YY	CESC	TCGA	VHTTS	DEG_SPOP_SBC_1	0.7208
p.T279I	TCGA-G4-6302	COAD	TCGA	VHTTS	DEG_SPOP_SBC_1	0.0833
p.D285Y	DO229035	LICA	ICGC	VHTTS	DEG_SPOP_SBC_1	0.25
p.T288M	DO38723	STAD	ICGC	VHTTS	DEG_SPOP_SBC_1	0.7423
p.A298T	SIDM01293	Colorectal Carcinoma	GDSC	VHTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86YD7	Protein FAM90A1	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.6922	More...
Q8IWE5	Pleckstrin homology domain-containing family M member 2	DEG_SPOP_SBC_1	288:292	VHTTS	SPOP	0.8723	More...
Q92618	Zinc finger protein 516	DEG_SPOP_SBC_1	1134:1138	VHTTS	SPOP	0.9673	More...
A6NDY2	Putative protein FAM90A10	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.6026	More...
A6NE21		DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.7681	More...
A6NKC0	Putative protein FAM90A7	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.7459	More...
A8MWA6	Putative protein FAM90A22	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9225	More...
A8MXZ1	Putative protein FAM90A23	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.5879	More...
D6RGX4	Putative protein FAM90A26	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.976	More...
P0C7V4	Putative protein FAM90A15P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.72	More...
P0C7W8	Putative protein FAM90A13P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9301	More...
P0C7W9	Putative protein FAM90A14	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9792	More...
P0C7X0	Putative protein FAM90A24P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.9832	More...
Q658T7	Putative protein FAM90A2P	DEG_SPOP_SBC_1	152:156	VHTTS	SPOP	0.8547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons