DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
VHTTS
Uniprot ID:
P0C7W9
Source protein:
Putative protein FAM90A14
Source gene:
FAM90A14
Class:
DEG_SPOP_SBC_1
Location:
152:156
E3 ligase:
SPOP
DEGRON score:
0.9792
ASA_SCORE:
80.3
COIL:
0.8502
CONS_SCORE:
0.2516
DSS_SCORE:
0.6188
HELIX:
0.0494
FCONS_SCORE:
0.5392
RIG_SCORE:
0.6873
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM90A14 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VHTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q86YD7
Protein FAM90A1
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.6922
More...
Q8IWE5
Pleckstrin homology domain-containing family M member 2
DEG_SPOP_SBC_1
288:292
VHTTS
SPOP
0.8723
More...
Q92618
Zinc finger protein 516
DEG_SPOP_SBC_1
1134:1138
VHTTS
SPOP
0.9673
More...
A6NDY2
Putative protein FAM90A10
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.6026
More...
A6NE21
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.7681
More...
A6NKC0
Putative protein FAM90A7
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.7459
More...
A8MWA6
Putative protein FAM90A22
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.9225
More...
A8MXZ1
Putative protein FAM90A23
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.5879
More...
D6RGX4
Putative protein FAM90A26
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.976
More...
P0C7V4
Putative protein FAM90A15P
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.72
More...
P0C7W8
Putative protein FAM90A13P
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.9301
More...
P0C7W9
Putative protein FAM90A14
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.9792
More...
P0C7X0
Putative protein FAM90A24P
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.9832
More...
Q658T7
Putative protein FAM90A2P
DEG_SPOP_SBC_1
152:156
VHTTS
SPOP
0.8547
More...