DegronMD

Uniprot ID: Q8IWE5

Source protein: Pleckstrin homology domain-containing family M member 2

Source gene: PLEKHM2

Class: DEG_SPOP_SBC_1

Location: 379:383

E3 ligase: SPOP

DEGRON score: 0.6967

ASA_SCORE: 86.98

COIL: 0.9176

CONS_SCORE: 0.316

DSS_SCORE: 0.9187

HELIX: 0.056

FCONS_SCORE: 0.9592

RIG_SCORE: 0.5068

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S389F	TCGA-BR-A4QL	STAD	TCGA	PSSTT	DEG_SPOP_SBC_1	0.1667
p.P379L	TCGA-FI-A2D4	UCEC	TCGA	PSSTT	DEG_SPOP_SBC_1	0.7582
p.L373R	DO233258	GACA	ICGC	PSSTT	DEG_SPOP_SBC_1	0.1667
p.P389S	DO233779	GACA	ICGC	PSSTT	DEG_SPOP_SBC_1	0.1667
p.K379N	DO228952	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	0.6918
p.S369F	DO38723	STAD	ICGC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.R388C	SIDM00980	Gastric Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.1944
p.R388C	ACH-000948	Gastric Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	0.1944
p.R388C	23132-87	stomach	COSMIC	PSSTT	DEG_SPOP_SBC_1	0.1944
p.L369P	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.L369P	ACH-000942	Leukemia	CCLE	PSSTT	DEG_SPOP_SBC_1	0.0556
p.G378R	huH-1	liver	COSMIC	PSSTT	DEG_SPOP_SBC_1	0.3056
p.G378R	TE-11	oesophagus	COSMIC	PSSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	279:283	PSSTT	SPOP	0.9606	More...
O75626	PR domain zinc finger protein 1	DEG_SPOP_SBC_1	330:334	PSSTT	SPOP	0.9804	More...
P10323	Acrosin	DEG_SPOP_SBC_1	372:376	PSSTT	SPOP	0.9214	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	389:393	PSSTT	SPOP	0.912	More...
P19801	Amiloride-sensitive amine oxidase [copper-containing]	DEG_SPOP_SBC_1	58:62	PSSTT	SPOP	0.6653	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	913:917	PSSTT	SPOP	0.9979	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1715:1719	PSSTT	SPOP	0.9877	More...
Q16186	Proteasomal ubiquitin receptor ADRM1	DEG_SPOP_SBC_1	218:222	PSSTT	SPOP	0.979	More...
Q6VAB6	Kinase suppressor of Ras 2	DEG_SPOP_SBC_1	521:525	PSSTT	SPOP	0.982	More...
Q8IVT5	Kinase suppressor of Ras 1	DEG_SPOP_SBC_1	448:452	PSSTT	SPOP	0.9811	More...
Q8IWE5	Pleckstrin homology domain-containing family M member 2	DEG_SPOP_SBC_1	379:383	PSSTT	SPOP	0.6967	More...
Q8IYB5	Stromal membrane-associated protein 1	DEG_SPOP_SBC_1	445:449	PSSTT	SPOP	0.9873	More...
Q8IZT6	Abnormal spindle-like microcephaly-associated protein	DEG_SPOP_SBC_1	564:568	PSSTT	SPOP	0.9996	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2083:2087	PSSTT	SPOP	0.6521	More...
Q9BZ23	Pantothenate kinase 2, mitochondrial	DEG_SPOP_SBC_1	35:39	PSSTT	SPOP	0.9845	More...
Q9UBW5	Bridging integrator 2	DEG_SPOP_SBC_1	363:367	PSSTT	SPOP	0.9824	More...
Q6P4D5	PABIR family member 1	DEG_SPOP_SBC_1	14:18	PSSTT	SPOP	0.8064	More...
Q6UXX5	Inter-alpha-trypsin inhibitor heavy chain H6	DEG_SPOP_SBC_1	914:918	PSSTT	SPOP	0.5086	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	111:115	PSSTT	SPOP	0.8482	More...
Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	DEG_SPOP_SBC_1	161:165	PSSTT	SPOP	0.9384	More...
Q9ULJ7	Ankyrin repeat domain-containing protein 50	DEG_SPOP_SBC_1	1235:1239	PSSTT	SPOP	0.9936	More...
Q9Y2D5	A-kinase anchor protein 2	DEG_SPOP_SBC_1	153:157	PSSTT	SPOP	0.9567	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1195:1199	PSSTT	SPOP	0.9043	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	351:355	PSSTT	SPOP	0.9888	More...
Q9HC44	Vasculin-like protein 1	DEG_SPOP_SBC_1	297:301	PSSTT	SPOP	0.9981	More...
Q9P2B7	Cilia- and flagella-associated protein 97	DEG_SPOP_SBC_1	234:238	PSSTT	SPOP	0.9913	More...
A6NM66	Uncharacterized protein encoded by LINC01548	DEG_SPOP_SBC_1	82:86	PSSTT	SPOP	0.6139	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTT

Degron related mutations and impact score

Drug responses associated with PLEKHM2 mutations

All proteins holding degron of PSSTT